Seroatlas · Human Serome Atlas

OVCH2

Ovochymase-2

Also known as: OVCH2_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q7RTZ1
Gene: OVCH2
Canonical length: 564 aa
Protein class: Predicted intracellular proteins, Predicted secreted proteins

OverviewNCBI Gene

No narrative summary is available for OVCH2 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

564 residues, UniProt reviewed canonical sequence.

>Q7RTZ1|OVCH2
     1  MLISRNKLIL LLGIVFFERG KSATLSLPKA PSCGQSLVKV QPWNYFNIFS RILGGSQVEK
    61  GSYPWQVSLK QRQKHICGGS IVSPQWVITA AHCIANRNIV STLNVTAGEY DLSQTDPGEQ
   121  TLTIETVIIH PHFSTKKPMD YDIALLKMAG AFQFGHFVGP ICLPELREQF EAGFICTTAG
   181  WGRLTEGGVL SQVLQEVNLP ILTWEECVAA LLTLKRPISG KTFLCTGFPD GGRDACQGDS
   241  GGSLMCRNKK GAWTLAGVTS WGLGCGRGWR NNVRKSDQGS PGIFTDISKV LPWIHEHIQT
   301  GNRRKSSRAW CSEQDVIVSG AEGKLHFPES LHLYYESKQR CVWTLLVPEE MHVLLSFSHL
   361  DVESCHHSYL SMYSLEDRPI GKFCGESLPS SILIGSNSLR LKFVSDATDN AARFNLTYKA
   421  LKPNYIPDSG CSYLTVLFEE GLIQSLNYPE NYSDKANCDW IFQASKHHLI KLSFQSLEIE
   481  ESGDCTSDYV TVHSDVERKK EIARLCGYDV PTPVLSPSSI MLISFHSDEN GTCRGFQATV
   541  SFIPKAGKKI ELPTLWFPVL ILVM

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against OVCH2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.3
Highest tissue expression: 177 nTPM

Expression across tissuesHPA

Tissue

epididymis: 177 nTPM
retina: 85 nTPM
skin: 8.6 nTPM
seminal vesicle: 5.4 nTPM
kidney: 4.9 nTPM
breast: 3.1 nTPM

Single-cell type

epididymal principal cells: 618 nCPM
rod photoreceptor cells: 377 nCPM
salivary myoepithelial cells: 58 nCPM
breast myoepithelial cells: 53 nCPM
cone photoreceptor cells: 37 nCPM
epididymal basal cells: 37 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

pons: 4 nTPM
cerebellum: 3.6 nTPM
thalamus: 3.6 nTPM
white matter: 3.3 nTPM
medulla oblongata: 2.8 nTPM
midbrain: 2.7 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.93
gnomAD pLI: 0
gnomAD missense Z: -0.07

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

extracellular region

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads OVCH2 as an antibody target. Whether an autoantibody or antibody against OVCH2 could matter depends on whether native OVCH2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

OVCH2 is annotated as secreted, so native OVCH2 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label OVCH2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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