Seroatlas · Human Serome Atlas

OVCH1

Ovochymase-1

Also known as: OVCH, OVCH1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q7RTY7
Gene: OVCH1
Ensembl: ENSG00000187950
Chromosome: 12
Canonical length: 1134 aa
Protein class: Enzymes, Predicted secreted proteins
Secretome location: Secreted in other tissues

OverviewNCBI Gene

Predicted to enable metal ion binding activity and serine-type endopeptidase activity. Predicted to be involved in proteolysis. Predicted to be located in extracellular region. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

1134 residues, UniProt reviewed canonical sequence.

>Q7RTY7|OVCH1
     1  MGLLASAGLL LLLVIGHPRS LGLKCGIRMV NMKSKEPAVG SRFFSRISSW RNSTVTGHPW
    61  QVSLKSDEHH FCGGSLIQED RVVTAAHCLD SLSEKQLKNI TVTSGEYSLF QKDKQEQNIP
   121  VSKIITHPEY NSREYMSPDI ALLYLKHKVK FGNAVQPICL PDSDDKVEPG ILCLSSGWGK
   181  ISKTSEYSNV LQEMELPIMD DRACNTVLKS MNLPPLGRTM LCAGFPDWGM DACQGDSGGP
   241  LVCRRGGGIW ILAGITSWVA GCAGGSVPVR NNHVKASLGI FSKVSELMDF ITQNLFTGLD
   301  RGQPLSKVGS RYITKALSSV QEVNGSQRGK GILDMEKQVG CDHDYVSLRS SSGVLFNQRS
   361  LMEDDGKQNK RVCGKILPSP LLAETSEAMV PFVSDTEDSG SGFELTVTAV QKSEAGSGCG
   421  SLAILVEEGT NHSAKYPDLY PSNTRCHWFI CAPEKHIIKL TFEDFAVKFS PNCIYDAVVI
   481  YGDSEEKHKL AKLCGMLTIT SIFSSSNMTV IYFKSDGKNR LQGFKARFTI LPSESLNKFE
   541  PKLPPQNNPV STVKAILHDV CGIPPFSPQW LSRRIAGGEE ACPHCWPWQV GLRFLGDYQC
   601  GGAIINPVWI LTAAHCVQLK NNPLSWTIIA GDHDRNLKES TEQVRRAKHI IVHEDFNTLS
   661  YDSDIALIQL SSPLEYNSVV RPVCLPHSAE PLFSSEICAV TGWGSISADG GLASRLQQIQ
   721  VHVLEREVCE HTYYSAHPGG ITEKMICAGF AASGEKDFCQ GDSGGPLVCR HENGPFVLYG
   781  IVSWGAGCVQ PWKPGVFARV MIFLDWIQSK INGPASLQTN NKCKTLKQQL PPPTPSPDSA
   841  SWPGCCSEAE LEKPRGFFPT PRYLLDYRGR LECSWVLRVS ASSMAKFTIE YLSLLGSPVC
   901  QDSVLIIYEE RHSKRKTAGG LHGRRLYSMT FMSPGPLVRV TFHALVRGAF GISYIVLKVL
   961  GPKDSKITRL SQSSNREHLV PCEDVLLTKP EGIMQIPRNS HRTTMGCQWR LVAPLNHIIQ
  1021  LNIINFPMKP TTFVCHGHLR VYEGFGPGKK LIASFAGTLA MILTKDILKR EKLNFINTYI
  1081  MHIWENSVYD NVRSVGKRKQ KKFASNLSYS MEAEKSRIQV PADLVPAKGS LSGS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against OVCH1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.36
Highest tissue expression: 1.4 nTPM

Expression across tissuesHPA

Tissue

lung: 1.4 nTPM
testis: 1.1 nTPM
spleen: 0.5 nTPM
blood vessel: 0.3 nTPM
adipose tissue: 0.2 nTPM
breast: 0.2 nTPM

Single-cell type

brain inhibitory neurons: 35 nCPM
retinal amacrine cells: 32 nCPM
other brain neurons: 31 nCPM
epicardial cells: 30 nCPM
early spermatids: 29 nCPM
adrenal medulla cells: 21 nCPM

Immune cell

neutrophil: 0.1 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM

Brain region

basal ganglia: 2.4 nTPM
cerebral cortex: 2 nTPM
hippocampal formation: 2 nTPM
hypothalamus: 1.8 nTPM
midbrain: 1.6 nTPM
thalamus: 1.4 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.22
gnomAD pLI: 0
gnomAD missense Z: 0.38

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

extracellular region

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads OVCH1 as an antibody target. Whether an autoantibody or antibody against OVCH1 could matter depends on whether native OVCH1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

OVCH1 is annotated as secreted, so native OVCH1 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label OVCH1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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