Seroatlas · Human Serome Atlas

OTULINL

Inactive ubiquitin thioesterase OTULINL

Also known as: FAM105A, FLJ11127, NET20, OTULL_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9NUU6
Gene: OTULINL
Ensembl: ENSG00000145569
Chromosome: 5
Canonical length: 356 aa
Protein class: Enzymes, Predicted membrane proteins
Subcellular location: Nucleoli,Cytosol

OverviewNCBI Gene

Located in cytoplasmic side of endoplasmic reticulum membrane and nuclear envelope. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

356 residues, UniProt reviewed canonical sequence.

>Q9NUU6|OTULINL
     1  MAATRSPTRA RERERSGAPA AGSDQVHSWM LATSQALDTV WRMAKGFVML AVSFLVAAIC
    61  YFRRLHLYSG HKLKWWIGYL QRKFKRNLSV EAEVDLLSYC AREWKGETPR NKLMRKAYEE
   121  LFWRHHIKCV RQVRRDNYDA LRSVLFQIFS QGISFPSWMK EKDIVKLPEK LLFSQGCNWI
   181  QQYSFGPEKY TGSNVFGKLR KYVELLKTQW TEFNGIRDYH KRGSMCNTLF SDAILEYKLY
   241  EALKFIMLYQ VTEVYEQMKT KKVIPSLFRL LFSRETSSDP LSFMMNHLNS VGDTCGLEQI
   301  DMFILGYSLE VKIKVFRLFK FNSRDFEVCY PEEPLRDWPE ISLLTENDRH YHIPVF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against OTULINL can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.31
Highest tissue expression: 29 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 29 nTPM
rectum: 13 nTPM
lung: 12 nTPM
colon: 12 nTPM
seminal vesicle: 9.4 nTPM
small intestine: 8.8 nTPM

Single-cell type

alveolar cells type 1: 325 nCPM
neutrophil progenitors: 296 nCPM
microglia: 289 nCPM
hofbauer cells: 198 nCPM
monocyte progenitors: 148 nCPM
cdc: 143 nCPM

Immune cell

myeloid DC: 34 nTPM
classical monocyte: 33 nTPM
plasmacytoid DC: 25 nTPM
total PBMC: 25 nTPM
NK-cell: 19 nTPM
intermediate monocyte: 16 nTPM

Brain region

choroid plexus: 12 nTPM
white matter: 9.4 nTPM
spinal cord: 6.7 nTPM
medulla oblongata: 6.3 nTPM
pons: 6 nTPM
thalamus: 5.6 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.24
gnomAD pLI: 0
DepMap mean gene effect: 0.05
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

FAM105
Peptidase family C101
Inactive ubiquitin thioesterase OTULINL

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of OTULINL in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

TMX2

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads OTULINL as an antibody target. Whether an autoantibody or antibody against OTULINL could matter depends on whether native OTULINL is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

OTULINL is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label OTULINL as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...