Seroatlas · Human Serome Atlas

OTOS

Otospiralin

Also known as: OTOSP, OTOSP_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8NHW6
Gene
OTOS
Ensembl
ENSG00000178602
Chromosome
2
Canonical length
89 aa
Protein class
Predicted secreted proteins
Secretome location
Secreted in other tissues

OverviewNCBI Gene

Otospiralin is synthesized by nonsensory cells (fibrocytes) of the inner ear, and downregulation of otospiralin in guinea pigs leads to deafness (Lavigne-Rebillard et al., 2003 [PubMed 12687421]).[supplied by OMIM, Mar 2008]

Canonical amino-acid sequenceUniProt

89 residues, UniProt reviewed canonical sequence.

>Q8NHW6|OTOS
     1  MQACMVPGLA LCLLLGPLAG AKPVQEEGDP YAELPAMPYW PFSTSDFWNY VQHFQALGAY
    61  PQIEDMARTF FAHFPLGSTL GFHVPYQED

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against OTOS can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Secreted
Secreted
Yes
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.48
Highest tissue expression
106 nTPM

Expression across tissuesHPA

Tissue

  • pituitary gland: 106 nTPM
  • thyroid gland: 41 nTPM
  • basal ganglia: 14 nTPM
  • amygdala: 13 nTPM
  • cerebral cortex: 7.9 nTPM
  • hippocampal formation: 6.3 nTPM

Single-cell type

  • epididymal efferent duct absorptive cells: 367 nCPM
  • somatotrophs: 59 nCPM
  • lactotrophs: 37 nCPM
  • pituitary stem cells: 13 nCPM
  • epididymal efferent duct ciliated cells: 3.8 nCPM
  • retinal amacrine cells: 1.4 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • hypothalamus: 12 nTPM
  • thalamus: 8.7 nTPM
  • white matter: 7.9 nTPM
  • midbrain: 6.7 nTPM
  • cerebral cortex: 6.4 nTPM
  • cerebellum: 5.7 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.93
gnomAD pLI
0
gnomAD missense Z
-0.12
DepMap mean gene effect
-0.06
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • Otospiralin
  • Otospiralin

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads OTOS as an antibody target. Whether an autoantibody or antibody against OTOS could matter depends on whether native OTOS is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

OTOS is annotated as secreted, so native OTOS circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label OTOS as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/OTOS. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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