OTOR
Otoraplin
Also known as: FDP, MIAL, MIAL1, OTOR_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q9NRC9
- Gene
- OTOR
- Ensembl
- ENSG00000125879
- Chromosome
- 20
- Canonical length
- 128 aa
- Protein class
- Predicted secreted proteins
- Secretome location
- Secreted in other tissues
OverviewNCBI Gene
This gene encodes a member of the melanoma-inhibiting activity gene family. The encoded protein is secreted via the Golgi apparatus and may function in cartilage development and maintenance. A frequent polymorphism in the translation start codon of this gene can abolish translation and may be associated with forms of deafness. [provided by RefSeq, Jul 2013]
Canonical amino-acid sequenceUniProt
128 residues, UniProt reviewed canonical sequence.
>Q9NRC9|OTOR
1 MARILLLFLP GLVAVCAVHG IFMDRLASKK LCADDECVYT ISLASAQEDY NAPDCRFINV
61 KKGQQIYVYS KLVKENGAGE FWAGSVYGDG QDEMGVVGYF PRNLVKEQRV YQEATKEVPT
121 TDIDFFCELocalizationUniProt · AlphaFold · HPA
Whether an antibody against OTOR can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Secreted
- Secreted
- Yes
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.37
- Highest tissue expression
- 0.1 nTPM
Expression across tissuesHPA
Tissue
- stomach: 0.1 nTPM
- adipose tissue: 0 nTPM
- adrenal gland: 0 nTPM
- amygdala: 0 nTPM
- appendix: 0 nTPM
- basal ganglia: 0 nTPM
Single-cell type
- schwann cells: 5.4 nCPM
- mucous neck cells: 0.8 nCPM
- myosatellite cells: 0.8 nCPM
- breast hormone-responsive cells: 0.6 nCPM
- epididymal principal cells: 0.4 nCPM
- innate lymphoid cells: 0.4 nCPM
Immune cell
- basophil: 0 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
- gdT-cell: 0 nTPM
- intermediate monocyte: 0 nTPM
- MAIT T-cell: 0 nTPM
Brain region
- midbrain: 0.1 nTPM
- amygdala: 0 nTPM
- basal ganglia: 0 nTPM
- cerebellum: 0 nTPM
- cerebral cortex: 0 nTPM
- choroid plexus: 0 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.51
- gnomAD pLI
- 0
- gnomAD missense Z
- -0.46
- DepMap mean gene effect
- -0.1
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Cellular components
Protein domainsUniProt · Pfam · InterPro
- SH3 domain
- SH3-like domain superfamily
- Variant SH3 domain
- Otoraplin, SH3 domain
- Otoraplin
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads OTOR as an antibody target. Whether an autoantibody or antibody against OTOR could matter depends on whether native OTOR is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
OTOR is annotated as secreted, so native OTOR circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.
Annotation status
The present source text does not explicitly label OTOR as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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