Seroatlas · Human Serome Atlas

OTOP3

Proton channel OTOP3

Also known as: OTOP3_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q7RTS5
Gene: OTOP3
Canonical length: 596 aa
Protein class: Predicted membrane proteins
Quaternary structure: Homodimer

OverviewNCBI Gene

No narrative summary is available for OTOP3 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

596 residues, UniProt reviewed canonical sequence.

>Q7RTS5|OTOP3
     1  MGRGARAAAA QSRWGRASRA SVSPGRTIRS APAVGEAQET EAAPEKENRV DVGAEERAAA
    61  TRPRQKSWLV RHFSLLLRRD RQAQKAGQLF SGLLALNVVF LGGAFICSMI FNKVAVTLGD
   121  VWILLATLKV LSLLWLLYYV ASTTRRPHAV LYQDPHAGPL WVRGSLVLFG SCTFCLNIFR
   181  VGYDVSHIRC KSQLDLVFSV IEMVFIGVQT WVLWKHCKDC VRVQTNFTRC GLMLTLATNL
   241  LLWVLAVTND SMHREIEAEL GILMEKSTGN ETNTCLCLNA TACEAFRRGF LMLYPFSTEY
   301  CLICCAVLFV MWKNVGRHVA PHMGAHPATA PFHLHGAIFG PLLGLLVLLA GVCVFVLFQI
   361  EASGPAIACQ YFTLYYAFYV AVLPTMSLAC LAGTAIHGLE ERELDTVKNP TRSLDVVLLM
   421  GAALGQMGIA YFSIVAIVAK RPHELLNRLI LAYSLLLILQ HIAQNLFIIE GLHRRPLWET
   481  VPEGLAGKQE AEPPRRGSLL ELGQGLQRAS LAYIHSYSHL NWKRRALKEI SLFLILCNIT
   541  LWMMPAFGIH PEFENGLEKD FYGYQIWFAI VNFGLPLGVF YRMHSVGGLV EVYLGA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against OTOP3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 12
Mean surface accessibility (rSASA): 0.34
Highest tissue expression: 75 nTPM

Expression across tissuesHPA

Tissue

duodenum: 75 nTPM
esophagus: 17 nTPM
small intestine: 13 nTPM
skin: 2.4 nTPM
salivary gland: 1.4 nTPM
vagina: 1.1 nTPM

Single-cell type

esophageal suprabasal cells: 68 nCPM
esophageal apical cells: 62 nCPM
enterocytes: 20 nCPM
suprabasal keratinocytes: 18 nCPM
esophageal basal cells: 15 nCPM
basal keratinocytes: 5.7 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebellum: 0.6 nTPM
cerebral cortex: 0.2 nTPM
pons: 0.2 nTPM
amygdala: 0.1 nTPM
basal ganglia: 0.1 nTPM
hippocampal formation: 0.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.15
gnomAD pLI: 0
gnomAD missense Z: -1.2
DepMap mean gene effect: 0.1
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

proton transmembrane transport

Molecular functions

Cellular components

plasma membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads OTOP3 as an antibody target. Whether an autoantibody or antibody against OTOP3 could matter depends on whether native OTOP3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

OTOP3 is annotated at the cell surface, where native OTOP3 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label OTOP3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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