Seroatlas · Human Serome Atlas

OTOP2

Proton channel OTOP2

Also known as: OTOP2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q7RTS6
Gene: OTOP2
Ensembl: ENSG00000183034
Chromosome: 17
Canonical length: 562 aa
Protein class: Predicted membrane proteins, Transporters
Subcellular location: Plasma membrane

OverviewNCBI Gene

Predicted to enable proton channel activity. Predicted to be involved in proton transmembrane transport. Predicted to be located in plasma membrane. Predicted to be active in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

562 residues, UniProt reviewed canonical sequence.

>Q7RTS6|OTOP2
     1  MSEELAQGPK ESPPAPRAGP REVWKKGGRL LSVLLAVNVL LLACTLISGG AFNKVAVYDT
    61  DVFALLTAMM LLATLWILFY LLRTVRCPCA VPYRDAHAGP IWLRGGLVLF GICTLIMDVF
   121  KTGYYSSFFE CQSAIKILHP LIQAVFVIIQ TYFLWVSAKD CVHVHLDLTW CGLMFTLTTN
   181  LAIWMAAVVD ESVHQSHSYS SSHSNASHAR LISDQHADNP VGGDSCLCST AVCQIFQQGY
   241  FYLYPFNIEY SLFASTMLYV MWKNVGRFLA STPGHSHTPT PVSLFRETFF AGPVLGLLLF
   301  VVGLAVFIIY EVQVSGDGSR TRQALVIYYS FNIVCLGLTT LVSLSGSIIY RFDRRAMDHH
   361  KNPTRTLDVA LLMGAALGQY AISYYSIVAV VAGTPQDLLA GLNLTHALLM IAQHTFQNMF
   421  IIESLHRGPP GAEPHSTHPK EPCQDLTFTN LDALHTLSAC PPNPGLVSPS PSDQREAVAI
   481  VSTPRSQWRR QCLKDISLFL LLCNVILWIM PAFGARPHFS NTVEVDFYGY SLWAVIVNIC
   541  LPFGIFYRMH AVSSLLEVYV LS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against OTOP2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 12
Mean surface accessibility (rSASA): 0.33
Highest tissue expression: 19 nTPM

Expression across tissuesHPA

Tissue

colon: 19 nTPM
rectum: 10 nTPM
testis: 4.7 nTPM
small intestine: 1.4 nTPM
esophagus: 0.9 nTPM
duodenum: 0.3 nTPM

Single-cell type

colonocytes: 123 nCPM
late spermatids: 36 nCPM
early spermatids: 17 nCPM
enterocytes: 12 nCPM
esophageal apical cells: 4.3 nCPM
neuroendocrine cells: 3.4 nCPM

Immune cell

myeloid DC: 0.1 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM

Brain region

cerebellum: 0.2 nTPM
cerebral cortex: 0.1 nTPM
amygdala: 0 nTPM
basal ganglia: 0 nTPM
choroid plexus: 0 nTPM
hippocampal formation: 0 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.4
gnomAD pLI: 0
gnomAD missense Z: 0.31
DepMap mean gene effect: -0.13
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads OTOP2 as an antibody target. Whether an autoantibody or antibody against OTOP2 could matter depends on whether native OTOP2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

OTOP2 is annotated at the cell surface, where native OTOP2 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label OTOP2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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