Seroatlas · Human Serome Atlas

OSGIN2

Oxidative stress-induced growth inhibitor 2

Also known as: C8orf1, hT41, OSGI2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9Y236
Gene: OSGIN2
Ensembl: ENSG00000164823
Chromosome: 8
Canonical length: 505 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoli

OverviewNCBI Gene

Predicted to enable growth factor activity. Predicted to be involved in negative regulation of cell growth. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

505 residues, UniProt reviewed canonical sequence.

>Q9Y236|OSGIN2
     1  MPLVEETSLL EDSSVTFPVV IIGNGPSGIC LSYMLSGYRP YLSSEAIHPN TILNSKLEEA
    61  RHLSIVDQDL EYLSEGLEGR SSNPVAVLFD TLLHPDADFG YDYPSVLHWK LEQHHYIPHV
   121  VLGKGPPGGA WHNMEGSMLT ISFGSWMELP GLKFKDWVSS KRRSLKGDRV MPEEIARYYK
   181  HYVKVMGLQK NFRENTYITS VSRLYRDQDD DDIQDRDIST KHLQIEKSNF IKRNWEIRGY
   241  QRIADGSHVP FCLFAENVAL ATGTLDSPAH LEIEGEDFPF VFHSMPEFGA AINKGKLRGK
   301  VDPVLIVGSG LTAADAVLCA YNSNIPVIHV FRRRVTDPSL IFKQLPKKLY PEYHKVYHMM
   361  CTQSYSVDSN LLSDYTSFPE HRVLSFKSDM KCVLQSVSGL KKIFKLSAAV VLIGSHPNLS
   421  FLKDQGCYLG HKSSQPITCK GNPVEIDTYT YECIKEANLF ALGPLVGDNF VRFLKGGALG
   481  VTRCLATRQK KKHLFVERGG GDGIA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against OSGIN2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.28
Highest tissue expression: 49 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 49 nTPM
parathyroid gland: 31 nTPM
ovary: 23 nTPM
testis: 21 nTPM
smooth muscle: 20 nTPM
adipose tissue: 18 nTPM

Single-cell type

late spermatids: 336 nCPM
early spermatids: 310 nCPM
alveolar cells type 1: 172 nCPM
late primary spermatocytes: 155 nCPM
pituicytes/fscs: 125 nCPM
transitional alveolar cells: 94 nCPM

Immune cell

basophil: 22 nTPM
neutrophil: 12 nTPM
eosinophil: 7 nTPM
memory B-cell: 3.3 nTPM
T-reg: 3.1 nTPM
memory CD4 T-cell: 2.7 nTPM

Brain region

hypothalamus: 35 nTPM
white matter: 34 nTPM
spinal cord: 28 nTPM
medulla oblongata: 23 nTPM
midbrain: 21 nTPM
pons: 20 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.43
gnomAD pLI: 0.59
gnomAD missense Z: 1.88
DepMap mean gene effect: 0.01
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 11% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

midbody

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads OSGIN2 as an antibody target. Whether an autoantibody or antibody against OSGIN2 could matter depends on whether native OSGIN2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

OSGIN2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label OSGIN2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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