OSCP1
Protein OSCP1
Also known as: C1orf102, NOR1, OSCP1_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q8WVF1
- Gene
- OSCP1
- Ensembl
- ENSG00000116885
- Chromosome
- 1
- Canonical length
- 389 aa
- Protein class
- Predicted intracellular proteins, Transporters
- Subcellular location
- Nucleoplasm,Nucleoli,Plasma membrane,Actin filaments,Primary cilium transition zone
OverviewNCBI Gene
Enables transmembrane transporter activity. Involved in xenobiotic detoxification by transmembrane export across the plasma membrane. Located in basal plasma membrane and cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
389 residues, UniProt reviewed canonical sequence.
>Q8WVF1|OSCP1
1 MSVRTLPLLF LNLGGEMLYI LDQRLRAQNI PGDKARKDEW TEVDRKRVLN DIISTMFNRK
61 FMEELFKPQE LYSKKALRTV YERLAHASIM KLNQASMDKL YDLMTMAFKY QVLLCPRPKD
121 VLLVTFNHLD TIKGFIRDSP TILQQVDETL RQLTEIYGGL SAGEFQLIRQ TLLIFFQDLH
181 IRVSMFLKDK VQNNNGRFVL PVSGPVPWGT EVPGLIRMFN NKGEEVKRIE FKHGGNYVPA
241 PKEGSFELYG DRVLKLGTNM YSVNQPVETH VSGSSKNLAS WTQESIAPNP LAKEELNFLA
301 RLMGGMEIKK PSGPEPGFRL NLFTTDEEEE QAALTRPEEL SYEVINIQAT QDQQRSEELA
361 RIMGEFEITE QPRLSTSKGD DLLAMMDELLocalizationUniProt · AlphaFold · HPA
Whether an antibody against OSCP1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Cell surface
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.34
- Highest tissue expression
- 79 nTPM
Expression across tissuesHPA
Tissue
- choroid plexus: 79 nTPM
- testis: 72 nTPM
- fallopian tube: 55 nTPM
- parathyroid gland: 28 nTPM
- pituitary gland: 22 nTPM
- retina: 21 nTPM
Single-cell type
- late primary spermatocytes: 542 nCPM
- early spermatids: 436 nCPM
- respiratory ciliated cells: 246 nCPM
- fallopian tube ciliated cells: 228 nCPM
- epididymal efferent duct ciliated cells: 196 nCPM
- endometrial ciliated cells: 123 nCPM
Immune cell
- plasmacytoid DC: 1.2 nTPM
- naive CD8 T-cell: 1 nTPM
- T-reg: 0.7 nTPM
- intermediate monocyte: 0.6 nTPM
- myeloid DC: 0.6 nTPM
- naive CD4 T-cell: 0.6 nTPM
Brain region
- choroid plexus: 64 nTPM
- midbrain: 29 nTPM
- hypothalamus: 25 nTPM
- medulla oblongata: 22 nTPM
- hippocampal formation: 20 nTPM
- thalamus: 19 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.14
- gnomAD pLI
- 0
- gnomAD missense Z
- 1.12
- DepMap mean gene effect
- -0.14
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
- Organic solute carrier protein 1
- Organic solute transport protein 1
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads OSCP1 as an antibody target. Whether an autoantibody or antibody against OSCP1 could matter depends on whether native OSCP1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
OSCP1 is annotated at the cell surface, where native OSCP1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.
Annotation status
The present source text does not explicitly label OSCP1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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