OSCAR
Osteoclast-associated immunoglobulin-like receptor
Also known as: OSCAR_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q8IYS5
- Gene
- OSCAR
- Ensembl
- ENSG00000170909
- Chromosome
- 19
- Canonical length
- 282 aa
- Protein class
- Predicted intracellular proteins, Predicted membrane proteins
- Subcellular location
- Nucleoplasm,Plasma membrane,Cytosol
- Secretome location
- Intracellular and membrane
OverviewNCBI Gene
Osteoclasts are multinucleated cells that resorb bone and are essential for bone homeostasis. This gene encodes an osteoclast-associated receptor (OSCAR), which is a member of the leukocyte receptor complex protein family that plays critical roles in the regulation of both innate and adaptive immune responses. The encoded protein may play a role in oxidative stress-mediated atherogenesis as well as monocyte adhesion. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2013]
Canonical amino-acid sequenceUniProt
282 residues, UniProt reviewed canonical sequence.
>Q8IYS5|OSCAR
1 MALVLILQLL TLWPLCHTDI TPSVPPASYH PKPWLGAQPA TVVTPGVNVT LRCRAPQPAW
61 RFGLFKPGEI APLLFRDVSS ELAEFFLEEV TPAQGGIYRC CYRRPDWGPG VWSQPSDVLE
121 LLVTEELPRP SLVALPGPVV GPGANVSLRC AGRLRNMSFV LYREGVAAPL QYRHSAQPWA
181 DFTLLGARAP GTYSCYYHTP SAPYVLSQRS EVLVISWEGE GPEARPASSA PGMQAPGPPP
241 SDPGAQAPSL SSFRPRGLVL QPLLPQTQDS WDPAPPPSDP GVLocalizationUniProt · AlphaFold · HPA
Whether an antibody against OSCAR can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Cell surface
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.44
- Highest tissue expression
- 29 nTPM
Expression across tissuesHPA
Tissue
- spleen: 29 nTPM
- lung: 28 nTPM
- bone marrow: 13 nTPM
- spinal cord: 4.9 nTPM
- blood vessel: 4.8 nTPM
- adipose tissue: 3.5 nTPM
Single-cell type
- microglia: 21 nCPM
- neutrophil progenitors: 20 nCPM
- neutrophils: 20 nCPM
- monocytes: 12 nCPM
- macrophages: 4.6 nCPM
- oocytes: 4.6 nCPM
Immune cell
- classical monocyte: 42 nTPM
- neutrophil: 39 nTPM
- intermediate monocyte: 28 nTPM
- non-classical monocyte: 27 nTPM
- eosinophil: 26 nTPM
- myeloid DC: 20 nTPM
Brain region
- white matter: 5 nTPM
- cerebral cortex: 4.3 nTPM
- medulla oblongata: 4 nTPM
- basal ganglia: 3.2 nTPM
- pons: 3.2 nTPM
- hypothalamus: 3 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.48
- gnomAD pLI
- 0
- gnomAD missense Z
- 0.28
- DepMap mean gene effect
- 0.07
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads OSCAR as an antibody target. Whether an autoantibody or antibody against OSCAR could matter depends on whether native OSCAR is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
OSCAR is annotated at the cell surface, where native OSCAR is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.
Annotation status
The present source text does not explicitly label OSCAR as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
Loading the interactive Seroatlas protein explorer...