Seroatlas · Human Serome Atlas

OSBPL7

Oxysterol-binding protein-related protein 7

Also known as: MGC71150, ORP7, OSBL7_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9BZF2
Gene: OSBPL7
Ensembl: ENSG00000006025
Chromosome: 17
Canonical length: 842 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Plasma membrane,Cytosol

OverviewNCBI Gene

This gene encodes a member of the oxysterol-binding protein (OSBP) family, a group of intracellular lipid receptors. Like most members, the encoded protein contains an N-terminal pleckstrin homology domain and a highly conserved C-terminal OSBP-like sterol-binding domain. Two transcript variants encoding the same isoform have been identified. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

842 residues, UniProt reviewed canonical sequence.

>Q9BZF2|OSBPL7
     1  MDFQERDPPF LPESAQSSKP SSAQQASELW EVVEEPRVRL GTEGVMPERQ EGHLLKKRKW
    61  PLKGWHKRYF VLEDGILHYA TTRQDITKGK LHGSIDVRLS VMSINKKAQR IDLDTEDNIY
   121  HLKIKSQDLF QSWVAQLRAH RLAHRLDMPR GSLPSTAHRK VPGAQLPTAA TASALPGLGP
   181  REKVSSWLRD SDGLDRCSHE LSECQGKLQE LHRLLQSLES LHRIPSAPVI PTHQASVTTE
   241  RPKKGKRTSR MWCTQSFAKD DTIGRVGRLH GSVPNLSRYL ESRDSSGTRG LPPTDYAHLQ
   301  RSFWALAQKV HSSLSSVLAA LTMERDQLRD MHQGSELSRM GVSEASTGQR RLHSLSTSSD
   361  TTADSFSSLN PEEQEALYMK GRELTPQLSQ TSILSLADSH TEFFDACEVL LSASSSENEG
   421  SEEEESCTSE ITTSLSEEML DLRGAERCQK GGCVPGRPMG PPRRRCLPAA SGPGADVSLW
   481  NILRNNIGKD LSKVSMPVQL NEPLNTLQRL CEELEYSSLL DQASRIADPC ERMVYIAAFA
   541  VSAYSSTYHR AGCKPFNPVL GETYECERPD RGFRFISEQV SHHPPISACH AESENFAFWQ
   601  DMKWKNKFWG KSLEIVPVGT VNVSLPRFGD HFEWNKVTSC IHNVLSGQRW IEHYGEVLIR
   661  NTQDSSCHCK ITFCKAKYWS SNVHEVQGAV LSRSGRVLHR LFGKWHEGLY RGPTPGGQCI
   721  WKPNSMPPDH ERNFGFTQFA LELNELTAEL KRSLPSTDTR LRPDQRYLEE GNIQAAEAQK
   781  RRIEQLQRDR RKVMEENNIV HQARFFRRQT DSSGKEWWVT NNTYWRLRAE PGYGNMDGAV
   841  LW

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against OSBPL7 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.4
Highest tissue expression: 32 nTPM

Expression across tissuesHPA

Tissue

stomach: 32 nTPM
colon: 22 nTPM
small intestine: 21 nTPM
duodenum: 21 nTPM
skeletal muscle: 19 nTPM
pancreas: 17 nTPM

Single-cell type

foveolar cells: 152 nCPM
goblet cells: 45 nCPM
colonocytes: 43 nCPM
enterocytes: 39 nCPM
mucous neck cells: 29 nCPM
enteric transient amplifying cells: 23 nCPM

Immune cell

gdT-cell: 1.8 nTPM
memory CD8 T-cell: 1.1 nTPM
memory B-cell: 1 nTPM
plasmacytoid DC: 1 nTPM
T-reg: 0.9 nTPM
total PBMC: 0.9 nTPM

Brain region

cerebral cortex: 11 nTPM
white matter: 9.1 nTPM
pons: 8.9 nTPM
medulla oblongata: 8.7 nTPM
amygdala: 8.6 nTPM
thalamus: 8.4 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.44
gnomAD pLI: 0
gnomAD missense Z: 2.13
DepMap mean gene effect: -0.12
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads OSBPL7 as an antibody target. Whether an autoantibody or antibody against OSBPL7 could matter depends on whether native OSBPL7 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

OSBPL7 is annotated at the cell surface, where native OSBPL7 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label OSBPL7 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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