Seroatlas · Human Serome Atlas

OSBPL5

Oxysterol-binding protein-related protein 5

Also known as: KIAA1534, OBPH1, ORP5, OSBL5_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9H0X9
Gene
OSBPL5
Ensembl
ENSG00000021762
Chromosome
11
Canonical length
879 aa
Protein class
Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins, Transporters
Subcellular location
Vesicles

OverviewNCBI Gene

This gene encodes a member of the oxysterol-binding protein (OSBP) family, a group of intracellular lipid receptors that play a key role in the maintenance of cholesterol balance in the body. Most members contain an N-terminal pleckstrin homology domain and a highly conserved C-terminal OSBP-like sterol-binding domain. This gene has been shown to be imprinted, with preferential expression from the maternal allele only in placenta. Transcript variants encoding different isoforms have been identified. [provided by RefSeq, Oct 2010]

Canonical amino-acid sequenceUniProt

879 residues, UniProt reviewed canonical sequence.

>Q9H0X9|OSBPL5
     1  MKEEAFLRRR FSLCPPSSTP QKVDPRKLTR NLLLSGDNEL YPLSPGKDME PNGPSLPRDE
    61  GPPTPSSATK VPPAEYRLCN GSDKECVSPT ARVTKKETLK AQKENYRQEK KRATRQLLSA
   121  LTDPSVVIMA DSLKIRGTLK SWTKLWCVLK PGVLLIYKTP KVGQWVGTVL LHCCELIERP
   181  SKKDGFCFKL FHPLDQSVWA VKGPKGESVG SITQPLPSSY LIFRAASESD GRCWLDALEL
   241  ALRCSSLLRL GTCKPGRDGE PGTSPDASPS SLCGLPASAT VHPDQDLFPL NGSSLENDAF
   301  SDKSERENPE ESDTETQDHS RKTESGSDQS ETPGAPVRRG TTYVEQVQEE LGELGEASQV
   361  ETVSEENKSL MWTLLKQLRP GMDLSRVVLP TFVLEPRSFL NKLSDYYYHA DLLSRAAVEE
   421  DAYSRMKLVL RWYLSGFYKK PKGIKKPYNP ILGETFRCCW FHPQTDSRTF YIAEQVSHHP
   481  PVSAFHVSNR KDGFCISGSI TAKSRFYGNS LSALLDGKAT LTFLNRAEDY TLTMPYAHCK
   541  GILYGTMTLE LGGKVTIECA KNNFQAQLEF KLKPFFGGST SINQISGKIT SGEEVLASLS
   601  GHWDRDVFIK EEGSGSSALF WTPSGEVRRQ RLRQHTVPLE EQTELESERL WQHVTRAISK
   661  GDQHRATQEK FALEEAQRQR ARERQESLMP WKPQLFHLDP ITQEWHYRYE DHSPWDPLKD
   721  IAQFEQDGIL RTLQQEAVAR QTTFLGSPGP RHERSGPDQR LRKASDQPSG HSQATESSGS
   781  TPESCPELSD EEQDGDFVPG GESPCPRCRK EARRLQALHE AILSIREAQQ ELHRHLSAML
   841  SSTARAAQAP TPGLLQSPRS WFLLCVFLAC QLFINHILK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against OSBPL5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.42
Highest tissue expression
36 nTPM

Expression across tissuesHPA

Tissue

  • cervix: 36 nTPM
  • blood vessel: 33 nTPM
  • colon: 27 nTPM
  • vagina: 27 nTPM
  • endometrium: 26 nTPM
  • skin: 25 nTPM

Single-cell type

  • nk-cells: 165 nCPM
  • retinal horizontal cells: 160 nCPM
  • endometrial stromal cells: 97 nCPM
  • decidual stromal cells: 90 nCPM
  • lymphatic endothelial cells: 76 nCPM
  • neutrophil progenitors: 75 nCPM

Immune cell

  • non-classical monocyte: 12 nTPM
  • NK-cell: 11 nTPM
  • gdT-cell: 9 nTPM
  • total PBMC: 5.2 nTPM
  • intermediate monocyte: 4.7 nTPM
  • classical monocyte: 3.6 nTPM

Brain region

  • pons: 133 nTPM
  • medulla oblongata: 85 nTPM
  • thalamus: 57 nTPM
  • midbrain: 45 nTPM
  • cerebral cortex: 40 nTPM
  • white matter: 37 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.56
gnomAD pLI
0
gnomAD missense Z
0.66
DepMap mean gene effect
0.05
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads OSBPL5 as an antibody target. Whether an autoantibody or antibody against OSBPL5 could matter depends on whether native OSBPL5 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

OSBPL5 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label OSBPL5 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/OSBPL5. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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