Seroatlas · Human Serome Atlas

ORMDL3

ORM1-like protein 3

Also known as: ORML3_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8N138
Gene
ORMDL3
Ensembl
ENSG00000172057
Chromosome
17
Canonical length
153 aa
Protein class
Disease related genes, Predicted membrane proteins
Subcellular location
Endoplasmic reticulum

OverviewNCBI Gene

Involved in ceramide metabolic process. Acts upstream of or within several processes, including negative regulation of B cell apoptotic process; negative regulation of ceramide biosynthetic process; and positive regulation of protein localization to nucleus. Located in endoplasmic reticulum. Part of serine palmitoyltransferase complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

153 residues, UniProt reviewed canonical sequence.

>Q8N138|ORMDL3
     1  MNVGTAHSEV NPNTRVMNSR GIWLSYVLAI GLLHIVLLSI PFVSVPVVWT LTNLIHNMGM
    61  YIFLHTVKGT PFETPDQGKA RLLTHWEQMD YGVQFTASRK FLTITPIVLY FLTSFYTKYD
   121  QIHFVLNTVS LMSVLIPKLP QLHGVRIFGI NKY

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ORMDL3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
3
Mean surface accessibility (rSASA)
0.33
Highest tissue expression
226 nTPM

Expression across tissuesHPA

Tissue

  • liver: 226 nTPM
  • adipose tissue: 140 nTPM
  • pancreas: 103 nTPM
  • choroid plexus: 99 nTPM
  • thymus: 74 nTPM
  • breast: 70 nTPM

Single-cell type

  • late spermatids: 537 nCPM
  • early spermatids: 319 nCPM
  • hepatocytes: 112 nCPM
  • late primary spermatocytes: 55 nCPM
  • paneth cells: 46 nCPM
  • epididymal principal cells: 46 nCPM

Immune cell

  • eosinophil: 61 nTPM
  • naive CD8 T-cell: 54 nTPM
  • naive CD4 T-cell: 44 nTPM
  • memory CD8 T-cell: 43 nTPM
  • gdT-cell: 40 nTPM
  • memory CD4 T-cell: 39 nTPM

Brain region

  • choroid plexus: 74 nTPM
  • cerebral cortex: 46 nTPM
  • thalamus: 45 nTPM
  • hippocampal formation: 43 nTPM
  • medulla oblongata: 43 nTPM
  • hypothalamus: 41 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about ORMDL3.

Disease | AllUniProt

Conditions ORMDL3 is implicated in, by any mechanism.

Disease | ImmuneIEDB

Conditions an epitope on ORMDL3 was assayed in.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.59
gnomAD pLI
0.78
gnomAD missense Z
1.32
DepMap mean gene effect
-0.14
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ORMDL3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ORMDL3 as an antibody target. Whether an autoantibody or antibody against ORMDL3 could matter depends on whether native ORMDL3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ORMDL3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ORMDL3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ORMDL3. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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