Seroatlas · Human Serome Atlas

ORMDL2

ORM1-like protein 2

Also known as: adoplin-2, HSPC160, MST095, MSTP095, ORML2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q53FV1
Gene: ORMDL2
Ensembl: ENSG00000123353
Chromosome: 12
Canonical length: 153 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins
Subcellular location: Endoplasmic reticulum

OverviewNCBI Gene

Involved in ceramide metabolic process. Acts upstream of or within negative regulation of ceramide biosynthetic process. Located in endoplasmic reticulum. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

153 residues, UniProt reviewed canonical sequence.

>Q53FV1|ORMDL2
     1  MNVGVAHSEV NPNTRVMNSR GIWLAYIILV GLLHMVLLSI PFFSIPVVWT LTNVIHNLAT
    61  YVFLHTVKGT PFETPDQGKA RLLTHWEQMD YGLQFTSSRK FLSISPIVLY LLASFYTKYD
   121  AAHFLINTAS LLSVLLPKLP QFHGVRVFGI NKY

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ORMDL2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 2
Mean surface accessibility (rSASA): 0.33
Highest tissue expression: 73 nTPM

Expression across tissuesHPA

Tissue

esophagus: 73 nTPM
choroid plexus: 56 nTPM
epididymis: 48 nTPM
rectum: 45 nTPM
liver: 45 nTPM
parathyroid gland: 42 nTPM

Single-cell type

esophageal apical cells: 805 nCPM
esophageal suprabasal cells: 282 nCPM
late primary spermatocytes: 215 nCPM
syncytiotrophoblasts: 189 nCPM
early spermatids: 167 nCPM
extravillous trophoblasts: 152 nCPM

Immune cell

plasmacytoid DC: 120 nTPM
non-classical monocyte: 109 nTPM
T-reg: 108 nTPM
eosinophil: 108 nTPM
memory B-cell: 94 nTPM
intermediate monocyte: 93 nTPM

Brain region

choroid plexus: 33 nTPM
white matter: 23 nTPM
medulla oblongata: 21 nTPM
thalamus: 20 nTPM
hypothalamus: 20 nTPM
cerebellum: 19 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.94
gnomAD pLI: 0.19
gnomAD missense Z: 0.46
DepMap mean gene effect: -0.12
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ORMDL2 as an antibody target. Whether an autoantibody or antibody against ORMDL2 could matter depends on whether native ORMDL2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ORMDL2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ORMDL2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...