Seroatlas · Human Serome Atlas

ORMDL1

ORM1-like protein 1

Also known as: ORML1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9P0S3
Gene: ORMDL1
Ensembl: ENSG00000128699
Chromosome: 2
Canonical length: 153 aa
Protein class: Predicted membrane proteins
Subcellular location: Endoplasmic reticulum

OverviewNCBI Gene

Involved in ceramide metabolic process. Acts upstream of or within negative regulation of ceramide biosynthetic process. Located in endoplasmic reticulum membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

153 residues, UniProt reviewed canonical sequence.

>Q9P0S3|ORMDL1
     1  MNVGVAHSEV NPNTRVMNSR GMWLTYALGV GLLHIVLLSI PFFSVPVAWT LTNIIHNLGM
    61  YVFLHAVKGT PFETPDQGKA RLLTHWEQLD YGVQFTSSRK FFTISPIILY FLASFYTKYD
   121  PTHFILNTAS LLSVLIPKMP QLHGVRIFGI NKY

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ORMDL1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 3
Mean surface accessibility (rSASA): 0.33
Highest tissue expression: 94 nTPM

Expression across tissuesHPA

Tissue

epididymis: 94 nTPM
spleen: 83 nTPM
skin: 80 nTPM
retina: 76 nTPM
lymph node: 70 nTPM
tonsil: 65 nTPM

Single-cell type

syncytiotrophoblasts: 276 nCPM
cytotrophoblasts: 261 nCPM
early primary spermatocytes: 206 nCPM
epididymal principal cells: 201 nCPM
kupffer cells: 199 nCPM
oocytes: 180 nCPM

Immune cell

basophil: 50 nTPM
non-classical monocyte: 49 nTPM
plasmacytoid DC: 46 nTPM
T-reg: 46 nTPM
naive CD4 T-cell: 45 nTPM
naive CD8 T-cell: 41 nTPM

Brain region

choroid plexus: 53 nTPM
cerebellum: 48 nTPM
hypothalamus: 46 nTPM
white matter: 44 nTPM
spinal cord: 40 nTPM
cerebral cortex: 39 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about ORMDL1.

Disease | ImmuneIEDB

Conditions an epitope on ORMDL1 was assayed in.

glioblastoma T cell

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.16
gnomAD pLI: 0.12
gnomAD missense Z: 0.78
DepMap mean gene effect: 0.07
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ORMDL1 as an antibody target. Whether an autoantibody or antibody against ORMDL1 could matter depends on whether native ORMDL1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ORMDL1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ORMDL1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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