Seroatlas · Human Serome Atlas

ORM2

Alpha-1-acid glycoprotein 2

Also known as: A1AG2_HUMAN, AGP-B, AGP-B', AGP2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P19652
Gene: ORM2
Ensembl: ENSG00000228278
Chromosome: 9
Canonical length: 201 aa
Protein class: FDA approved drug targets, Plasma proteins, Predicted secreted proteins
Subcellular location: Golgi apparatus,Vesicles
Secretome location: Secreted to blood

OverviewNCBI Gene

This gene encodes a key acute phase plasma protein. Because of its increase due to acute inflammation, this protein is classified as an acute-phase reactant. The specific function of this protein has not yet been determined; however, it may be involved in aspects of immunosuppression. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

201 residues, UniProt reviewed canonical sequence.

>P19652|ORM2
     1  MALSWVLTVL SLLPLLEAQI PLCANLVPVP ITNATLDRIT GKWFYIASAF RNEEYNKSVQ
    61  EIQATFFYFT PNKTEDTIFL REYQTRQNQC FYNSSYLNVQ RENGTVSRYE GGREHVAHLL
   121  FLRDTKTLMF GSYLDDEKNW GLSFYADKPE TTKEQLGEFY EALDCLCIPR SDVMYTDWKK
   181  DKCEPLEKQH EKERKQEEGE S

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ORM2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.32
Highest tissue expression: 8,193 nTPM

Expression across tissuesHPA

Tissue

liver: 8,193 nTPM
bone marrow: 28 nTPM
prostate: 23 nTPM
stomach: 21 nTPM
spleen: 6.2 nTPM
lung: 6.1 nTPM

Single-cell type

hepatocytes: 12,409 nCPM
cholangiocytes: 249 nCPM
kupffer cells: 153 nCPM
hepatic stellate cells: 71 nCPM
gastric chief cells: 64 nCPM
parietal cells: 58 nCPM

Immune cell

neutrophil: 13 nTPM
classical monocyte: 0.3 nTPM
gdT-cell: 0.1 nTPM
non-classical monocyte: 0.1 nTPM
total PBMC: 0.1 nTPM
basophil: 0 nTPM

Brain region

basal ganglia: 1.2 nTPM
cerebral cortex: 1 nTPM
midbrain: 1 nTPM
medulla oblongata: 0.8 nTPM
spinal cord: 0.8 nTPM
white matter: 0.8 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.35
gnomAD pLI: 0
gnomAD missense Z: -1.19
DepMap mean gene effect: 0.12
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ORM2 as an antibody target. Whether an autoantibody or antibody against ORM2 could matter depends on whether native ORM2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ORM2 is annotated as secreted, so native ORM2 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label ORM2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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