Seroatlas · Human Serome Atlas

OR9G4

Olfactory receptor 9G4

Also known as: OR9G4_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8NGQ1
Gene: OR9G4
Canonical length: 327 aa
Protein class: Predicted membrane proteins

OverviewNCBI Gene

No narrative summary is available for OR9G4 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

327 residues, UniProt reviewed canonical sequence.

>Q8NGQ1|OR9G4
     1  MIFPSHDSQA FTSVDMEVGN CTILTEFILL GFSADSQWQP ILFGVFLMLY LITLSGNMTL
    61  VILIRTDSHL HTPMYFFIGN LSFLDFWYTS VYTPKILASC VSEDKRISLA GCGAQLFFSC
   121  VVAYTECYLL AAMAYDRHAA ICNPLLYSGT MSTALCTGLV AGSYIGGFLN AIAHTANTFR
   181  LHFCGKNIID HFFCDAPPLV KMSCTNTRVY EKVLLGVVGF TVLSSILAIL ISYVNILLAI
   241  LRIHSASGRH KAFSTCASHL ISVMLFYGSL LFMYSRPSST YSLERDKVAA LFYTVINPLL
   301  NPLIYSLRNK DIKEAFRKAT QTIQPQT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against OR9G4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 7
Mean surface accessibility (rSASA): 0.3
Highest tissue expression: 0 nTPM

Expression across tissuesHPA

Tissue

adipose tissue: 0 nTPM
adrenal gland: 0 nTPM
amygdala: 0 nTPM
appendix: 0 nTPM
basal ganglia: 0 nTPM
blood vessel: 0 nTPM

Single-cell type

podocytes: 0.5 nCPM
distal convoluted tubule cells: 0.1 nCPM
proximal tubule cells: 0.1 nCPM
renal collecting duct intercalated cells: 0.1 nCPM
adipocytes: 0 nCPM
adrenal cortex cells: 0 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

amygdala: 0 nTPM
basal ganglia: 0 nTPM
cerebellum: 0 nTPM
cerebral cortex: 0 nTPM
choroid plexus: 0 nTPM
hippocampal formation: 0 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.86
gnomAD pLI: 0
gnomAD missense Z: -1.29
DepMap mean gene effect: -0.07
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

plasma membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads OR9G4 as an antibody target. Whether an autoantibody or antibody against OR9G4 could matter depends on whether native OR9G4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

OR9G4 is annotated at the cell surface, where native OR9G4 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label OR9G4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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