Seroatlas · Human Serome Atlas

OR9G1

Olfactory receptor 9G1

Also known as: OR9G1_HUMAN, OR9G5

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8NH87
Gene: OR9G1
Ensembl: ENSG00000174914
Chromosome: 11
Canonical length: 305 aa
Protein class: G-protein coupled receptors, Predicted membrane proteins

OverviewNCBI Gene

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

305 residues, UniProt reviewed canonical sequence.

>Q8NH87|OR9G1
     1  MQRSNHTVTE FILLGFTTDP GMQLGLFVVF LGVYSLTVVG NSTLIVLICN DSCLHTPMYF
    61  FTGNLSFLDL WYSSVYTPKI LVTCISEDKS ISFAGCLCQF FFSAGLAYSE CYLLAAVAYD
   121  RYVAISKPLL YAQAMSIKLC ALLVAVSYCG GFINSSIITK KTFSFNFCRE NIIDDFFCDL
   181  LPLVELACGE KGGYKIMMYF LLASNVICPA VLILASYLFI ITSVLRISSS KGYLKAFSTC
   241  SSHLTSVTLY YGSILYIYAL PRSSYSFDMD KIVSTFYTVV FPMLNLMIYS LRNKDVKEAL
   301  KKLLP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against OR9G1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 7
Mean surface accessibility (rSASA): 0.27
Highest tissue expression: 0 nTPM

Expression across tissuesHPA

Tissue

adipose tissue: 0 nTPM
adrenal gland: 0 nTPM
amygdala: 0 nTPM
appendix: 0 nTPM
basal ganglia: 0 nTPM
blood vessel: 0 nTPM

Single-cell type

adipocytes: 0 nCPM
adrenal cortex cells: 0 nCPM
adrenal medulla cells: 0 nCPM
alveolar cells type 1: 0 nCPM
alveolar cells type 2: 0 nCPM
astrocytes: 0 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebellum: 1.5 nTPM
hypothalamus: 0.5 nTPM
pons: 0.5 nTPM
white matter: 0.5 nTPM
cerebral cortex: 0.4 nTPM
medulla oblongata: 0.4 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.78
gnomAD pLI: 0
gnomAD missense Z: -1.64
DepMap mean gene effect: -0.2
DepMap dependency class: selective

OntologyGO

Molecular functions

Cellular components

plasma membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads OR9G1 as an antibody target. Whether an autoantibody or antibody against OR9G1 could matter depends on whether native OR9G1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

OR9G1 is annotated at the cell surface, where native OR9G1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label OR9G1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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