Seroatlas · Human Serome Atlas

OR9A4

Olfactory receptor 9A4

Also known as: OR9A4_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8NGU2
Gene: OR9A4
Ensembl: ENSG00000258083
Chromosome: 7
Canonical length: 314 aa
Protein class: G-protein coupled receptors, Predicted membrane proteins

OverviewNCBI Gene

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

314 residues, UniProt reviewed canonical sequence.

>Q8NGU2|OR9A4
     1  MLMNYSSATE FYLLGFPGSE ELHHILFAIF FFFYLVTLMG NTVIIMIVCV DKRLQSPMYF
    61  FLGHLSALEI LVTTIIVPVM LWGLLLPGMQ TIYLSACVVQ LFLYLAVGTT EFALLGAMAV
   121  DRYVAVCNPL RYNIIMNRHT CNFVVLVSWV FGFLFQIWPV YVMFQLTYCK SNVVNNFFCD
   181  RGQLLKLSCN NTLFTEFILF LMAVFVLFGS LIPTIVSNAY IISTILKIPS SSGRRKSFST
   241  CASHFTCVVI GYGSCLFLYV KPKQTQAADY NWVVSLMVSV VTPFLNPFIF TLRNDKVIEA
   301  LRDGVKRCCQ LFRN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against OR9A4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 7
Mean surface accessibility (rSASA): 0.27
Highest tissue expression: 0.2 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 0.2 nTPM
testis: 0.1 nTPM
adipose tissue: 0 nTPM
adrenal gland: 0 nTPM
amygdala: 0 nTPM
appendix: 0 nTPM

Single-cell type

adipocytes: 0 nCPM
adrenal cortex cells: 0 nCPM
adrenal medulla cells: 0 nCPM
alveolar cells type 1: 0 nCPM
alveolar cells type 2: 0 nCPM
astrocytes: 0 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

midbrain: 1 nTPM
hypothalamus: 0.7 nTPM
amygdala: 0.6 nTPM
cerebral cortex: 0.6 nTPM
hippocampal formation: 0.6 nTPM
medulla oblongata: 0.6 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.92
gnomAD pLI: 0
gnomAD missense Z: -0.75
DepMap mean gene effect: -0.09
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

Cellular components

plasma membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads OR9A4 as an antibody target. Whether an autoantibody or antibody against OR9A4 could matter depends on whether native OR9A4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

OR9A4 is annotated at the cell surface, where native OR9A4 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label OR9A4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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