Seroatlas · Human Serome Atlas

OR8S1

Olfactory receptor 8S1

Also known as: OR8S1_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8NH09
Gene: OR8S1
Canonical length: 359 aa
Protein class: Predicted membrane proteins

OverviewNCBI Gene

No narrative summary is available for OR8S1 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

359 residues, UniProt reviewed canonical sequence.

>Q8NH09|OR8S1
     1  MALGNHSTIT EFLLLGLSAD PNIRALLFVL FLGIYLLTIM ENLMLLLMIR ADSCLHKPMY
    61  FFLSHLSFVD LCFSSVIVPK MLENLLSQRK TISVEGCLAQ VFFVFVTAGT EACLLSGMAY
   121  DRHAAICRPL LYGQIMGKQL YMHLVWGSWG LGFLDALINV LLAVNMVFCE AKIIHHYSYE
   181  MPSLLPLSCS DISRSLIALL CSTLLHGLGN FLLVFLSYTR IISTILSISS TSGRSKAFST
   241  CSAHLTAVTL YYGSGLLRHL MPNSGSPIEL IFSVQYTVVT PMLNSLIYSL KNKEVKGERS
   301  LRDSSHLPQL HKGQARWKRP AFTEGRREPG HPELSIPVTP QPQGACACSA LRAAPTALP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against OR8S1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 7
Mean surface accessibility (rSASA): 0.35
Highest tissue expression: 0.1 nTPM

Expression across tissuesHPA

Tissue

duodenum: 0.1 nTPM
ovary: 0.1 nTPM
adipose tissue: 0 nTPM
adrenal gland: 0 nTPM
amygdala: 0 nTPM
appendix: 0 nTPM

Single-cell type

distal convoluted tubule cells: 0.1 nCPM
renal connecting tubule cells: 0.1 nCPM
adipocytes: 0 nCPM
adrenal cortex cells: 0 nCPM
adrenal medulla cells: 0 nCPM
alveolar cells type 1: 0 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

pons: 0.8 nTPM
cerebral cortex: 0.7 nTPM
medulla oblongata: 0.4 nTPM
white matter: 0.4 nTPM
amygdala: 0.3 nTPM
hippocampal formation: 0.3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.88
gnomAD pLI: 0
gnomAD missense Z: -0.36
DepMap mean gene effect: -0.11
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 0% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

signal transduction

Molecular functions

Cellular components

plasma membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads OR8S1 as an antibody target. Whether an autoantibody or antibody against OR8S1 could matter depends on whether native OR8S1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

OR8S1 is annotated at the cell surface, where native OR8S1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label OR8S1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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