Seroatlas · Human Serome Atlas

OR8J3

Olfactory receptor 8J3

Also known as: OR8J3_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8NGG0
Gene: OR8J3
Ensembl: ENSG00000167822
Chromosome: 11
Canonical length: 315 aa
Protein class: G-protein coupled receptors, Predicted membrane proteins

OverviewNCBI Gene

Predicted to enable G protein-coupled receptor activity and olfactory receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway and detection of chemical stimulus involved in sensory perception of smell. Predicted to be located in plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

315 residues, UniProt reviewed canonical sequence.

>Q8NGG0|OR8J3
     1  MAPENFTRVT EFILTGVSSC PELQIPLFLV FLVLYVLTMA GNLGIITLTS VDSRLQNPMY
    61  FFLRHLAIIN LGNSTVIAPK MLMNFLVKKK TTSFYECATQ LGGFLFFIVS EVMMLAVMAY
   121  DRYVAICNPL LYMVVVSRRL CLLLVSLTYL YGFSTAIVVS PCIFSVSYCS SNIINHFYCD
   181  IAPLLALSCS DTYIPETIVF ISAATNLVFS MITVLVSYFN IVLSILRIRS PEGRKKAFST
   241  CASHMIAVTV FYGTMLFMYL QPQTNHSLDT DKMASVFYTL VIPMLNPLIY SLRNNDVNVA
   301  LKKFMENPCY SFKSM

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against OR8J3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 7
Mean surface accessibility (rSASA): 0.27
Highest tissue expression: 0 nTPM

Expression across tissuesHPA

Tissue

adipose tissue: 0 nTPM
adrenal gland: 0 nTPM
amygdala: 0 nTPM
appendix: 0 nTPM
basal ganglia: 0 nTPM
blood vessel: 0 nTPM

Single-cell type

differentiating spermatogonia: 0.1 nCPM
adipocytes: 0 nCPM
adrenal cortex cells: 0 nCPM
adrenal medulla cells: 0 nCPM
alveolar cells type 1: 0 nCPM
alveolar cells type 2: 0 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

amygdala: 0 nTPM
basal ganglia: 0 nTPM
cerebellum: 0 nTPM
cerebral cortex: 0 nTPM
choroid plexus: 0 nTPM
hippocampal formation: 0 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.92
gnomAD pLI: 0.07
gnomAD missense Z: -0.62
DepMap mean gene effect: -0.09
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 1% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

Cellular components

plasma membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads OR8J3 as an antibody target. Whether an autoantibody or antibody against OR8J3 could matter depends on whether native OR8J3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

OR8J3 is annotated at the cell surface, where native OR8J3 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label OR8J3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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