Seroatlas · Human Serome Atlas

OR8G5

Olfactory receptor 8G5

Also known as: OR8G5_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8NG78
Gene: OR8G5
Canonical length: 346 aa
Protein class: Predicted membrane proteins

OverviewNCBI Gene

No narrative summary is available for OR8G5 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

346 residues, UniProt reviewed canonical sequence.

>Q8NG78|OR8G5
     1  MIIYKQGITF LQKENNNTIH LNTMFFLSPA ETHQRMAAEN HSFVTKFILV GLTEKSELQL
    61  PLFLVFLGIY VVTVLGNLGM ITLIGLSSHL HTPMYCFLSS LSFIDFCHST VITPKMLVNF
   121  VTEKNIISYP ECMTQLYFFL VFAIAECHML AAMAYDGYVA ICSPLLYSII ISNKACFSLI
   181  LVVYVIGLIC ASAHIGCMFR VQFCKFDVIN HYFCDLISIL KLSCSSTYIN ELLILIFSGI
   241  NILVPSLTIL SSYIFIIASI LRIRYTEGRS KAFSTCSSHI SAVSVFFGSA AFMYLQPSSV
   301  SSMDQGKVSS VFYTIVVPML NPLIYSLRNK DVHVALKKTL GKRTFL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against OR8G5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 7
Mean surface accessibility (rSASA): 0.32
Highest tissue expression: 2.5 nTPM

Expression across tissuesHPA

Tissue

testis: 2.5 nTPM
colon: 0.1 nTPM
lung: 0.1 nTPM
placenta: 0.1 nTPM
adipose tissue: 0 nTPM
adrenal gland: 0 nTPM

Single-cell type

late spermatids: 46 nCPM
oocytes: 37 nCPM
early spermatids: 30 nCPM
late primary spermatocytes: 25 nCPM
early primary spermatocytes: 4.8 nCPM
mast cells: 3.8 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebral cortex: 0.3 nTPM
hypothalamus: 0.3 nTPM
basal ganglia: 0.1 nTPM
amygdala: 0 nTPM
cerebellum: 0 nTPM
choroid plexus: 0 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.56
gnomAD pLI: 0.02
gnomAD missense Z: -0.54
DepMap mean gene effect: -0.04
DepMap dependency class: none

OntologyGO

Biological processes

Molecular functions

Cellular components

plasma membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads OR8G5 as an antibody target. Whether an autoantibody or antibody against OR8G5 could matter depends on whether native OR8G5 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

OR8G5 is annotated at the cell surface, where native OR8G5 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label OR8G5 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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