Seroatlas · Human Serome Atlas

OR8G1

Olfactory receptor 8G1

Also known as: HSTPCR25, OR8G1_HUMAN, OR8G1P, TPCR25

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q15617
Gene: OR8G1
Ensembl: ENSG00000197849
Chromosome: 11
Canonical length: 311 aa
Protein class: G-protein coupled receptors, Predicted membrane proteins

OverviewNCBI Gene

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. This family member represents a polymorphic pseudogene, whereby some individuals have a functional allele that encodes a full-length protein, while others have a non-functional allele due to the presence of an early stop codon and a 3' end deletion. [provided by RefSeq, Feb 2014]

Canonical amino-acid sequenceUniProt

311 residues, UniProt reviewed canonical sequence.

>Q15617|OR8G1
     1  MSGENNSSVT EFILAGLSEQ PELQLPLFLL FLGIYVVTVV GNLGMTTLIW LSSHLHTPMY
    61  YFLSSLSFID FCHSTVITPK MLVNFVTEKN IISYPECMTQ LYFFLVFAIA ECHMLAAMAY
   121  DRYMAICSPL LYSVIISNKA CFSLILGVYI IGLVCASVHT GCMFRVQFCK FDLINHYFCD
   181  LLPLLKLSCS SIYVNKLLIL CVGAFNILVP SLTILCSYIF IIASILHIRS TEGRSKAFST
   241  CSSHMLAVVI FFGSAAFMYL QPSSISSMDQ GKVSSVFYTI IVPMLNPLIY SLRNKDVHVS
   301  LKKMLQRRTL L

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against OR8G1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 7
Mean surface accessibility (rSASA): 0.27
Highest tissue expression: 0.2 nTPM

Expression across tissuesHPA

Tissue

testis: 0.2 nTPM
bone marrow: 0.1 nTPM
retina: 0.1 nTPM
adipose tissue: 0 nTPM
adrenal gland: 0 nTPM
amygdala: 0 nTPM

Single-cell type

late primary spermatocytes: 13 nCPM
early spermatids: 12 nCPM
late spermatids: 6.1 nCPM
early primary spermatocytes: 5.7 nCPM
undifferentiated spermatogonia: 5.1 nCPM
differentiating spermatogonia: 1.6 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebellum: 3 nTPM
hypothalamus: 2.1 nTPM
cerebral cortex: 2 nTPM
white matter: 2 nTPM
choroid plexus: 1.9 nTPM
pons: 1.9 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.63
gnomAD pLI: 0
gnomAD missense Z: -0.76

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads OR8G1 as an antibody target. Whether an autoantibody or antibody against OR8G1 could matter depends on whether native OR8G1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

OR8G1 is annotated at the cell surface, where native OR8G1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label OR8G1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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