Seroatlas · Human Serome Atlas

OR8D1

Olfactory receptor 8D1

Also known as: OR8D1_HUMAN, OR8D3, OST004

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8WZ84
Gene: OR8D1
Ensembl: ENSG00000196341
Chromosome: 11
Canonical length: 308 aa
Protein class: G-protein coupled receptors, Predicted membrane proteins

OverviewNCBI Gene

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

308 residues, UniProt reviewed canonical sequence.

>Q8WZ84|OR8D1
     1  MTMENYSMAA QFVLDGLTQQ AELQLPLFLL FLGIYVVTVV GNLGMILLIA VSPLLHTPMY
    61  YFLSSLSFVD FCYSSVITPK MLVNFLGKKN TILYSECMVQ LFFFVVFVVA EGYLLTAMAY
   121  DRYVAICSPL LYNAIMSSWV CSLLVLAAFF LGFLSALTHT SAMMKLSFCK SHIINHYFCD
   181  VLPLLNLSCS NTHLNELLLF IIAGFNTLVP TLAVAVSYAF ILYSILHIRS SEGRSKAFGT
   241  CSSHLMAVVI FFGSITFMYF KPPSSNSLDQ EKVSSVFYTT VIPMLNPLIY SLRNKDVKKA
   301  LRKVLVGK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against OR8D1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 7
Mean surface accessibility (rSASA): 0.27
Highest tissue expression: 0.6 nTPM

Expression across tissuesHPA

Tissue

testis: 0.6 nTPM
bone marrow: 0.1 nTPM
choroid plexus: 0.1 nTPM
epididymis: 0.1 nTPM
retina: 0.1 nTPM
skin: 0.1 nTPM

Single-cell type

adipocytes: 0.9 nCPM
late primary spermatocytes: 0.8 nCPM
late spermatids: 0.7 nCPM
mast cells: 0.7 nCPM
other brain neurons: 0.7 nCPM
early primary spermatocytes: 0.3 nCPM

Immune cell

eosinophil: 0.1 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebral cortex: 2.8 nTPM
hypothalamus: 2.5 nTPM
basal ganglia: 2.1 nTPM
white matter: 2.1 nTPM
amygdala: 1.7 nTPM
cerebellum: 1.7 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD missense Z: -0.45
DepMap mean gene effect: 0.02
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

plasma membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads OR8D1 as an antibody target. Whether an autoantibody or antibody against OR8D1 could matter depends on whether native OR8D1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

OR8D1 is annotated at the cell surface, where native OR8D1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label OR8D1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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