OR8B8
Olfactory receptor 8B8
Also known as: OR8B8_HUMAN, TPCR85
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q15620
- Gene
- OR8B8
- Ensembl
- ENSG00000197125
- Chromosome
- 11
- Canonical length
- 311 aa
- Protein class
- G-protein coupled receptors, Predicted membrane proteins
OverviewNCBI Gene
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]
Canonical amino-acid sequenceUniProt
311 residues, UniProt reviewed canonical sequence.
>Q15620|OR8B8
1 MAAENSSFVT QFILAGLTDQ PGVQIPLFFL FLGFYVVTVV GNLGLITLIR LNSHLHTPMY
61 FFLYNLSFID FCYSSVITPK MLMSFVLKKN SISYAGCMTQ LFFFLFFVVS ESFILSAMAY
121 DRYVAICNPL LYMVTMSPQV CFLLLLGVYG MGFAGAMAHT ACMMGVTFCA NNLVNHYMCD
181 ILPLLECACT STYVNELVVF VVVGIDIGVP TVTIFISYAL ILSSIFHIDS TEGRSKAFST
241 CSSHIIAVSL FFGSGAFMYL KPFSLLAMNQ GKVSSLFYTT VVPMLNPLIY SLRNKDVKVA
301 LKKILNKNAF SLocalizationUniProt · AlphaFold · HPA
Whether an antibody against OR8B8 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Cell surface
- Secreted
- No
- Transmembrane segments
- 7
- Mean surface accessibility (rSASA)
- 0.27
- Highest tissue expression
- 0.1 nTPM
Expression across tissuesHPA
Tissue
- bone marrow: 0.1 nTPM
- skin: 0.1 nTPM
- adipose tissue: 0 nTPM
- adrenal gland: 0 nTPM
- amygdala: 0 nTPM
- appendix: 0 nTPM
Single-cell type
- mast cells: 1.1 nCPM
- other brain neurons: 0.2 nCPM
- adipocytes: 0 nCPM
- adrenal cortex cells: 0 nCPM
- adrenal medulla cells: 0 nCPM
- alveolar cells type 1: 0 nCPM
Immune cell
- basophil: 0.1 nTPM
- neutrophil: 0.1 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
- gdT-cell: 0 nTPM
- intermediate monocyte: 0 nTPM
Brain region
- cerebral cortex: 4.1 nTPM
- hypothalamus: 2.4 nTPM
- white matter: 2 nTPM
- basal ganglia: 1.8 nTPM
- pons: 1.7 nTPM
- thalamus: 1.7 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.63
- gnomAD pLI
- 0.01
- gnomAD missense Z
- -0.24
- DepMap mean gene effect
- 0.02
- DepMap dependency class
- none
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 1% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads OR8B8 as an antibody target. Whether an autoantibody or antibody against OR8B8 could matter depends on whether native OR8B8 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
OR8B8 is annotated at the cell surface, where native OR8B8 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.
Annotation status
The present source text does not explicitly label OR8B8 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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