Seroatlas · Human Serome Atlas

OR8B12

Olfactory receptor 8B12

Also known as: OR8BC_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8NGG6
Gene: OR8B12
Ensembl: ENSG00000170953
Chromosome: 11
Canonical length: 310 aa
Protein class: G-protein coupled receptors, Predicted membrane proteins

OverviewNCBI Gene

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

310 residues, UniProt reviewed canonical sequence.

>Q8NGG6|OR8B12
     1  MAAKNSSVTE FILEGLTHQP GLRIPLFFLF LGFYTVTVVG NLGLITLIGL NSHLHTPMYF
    61  FLFNLSLIDF CFSTTITPKM LMSFVSRKNI ISFTGCMTQL FFFCFFVVSE SFILSAMAYD
   121  RYVAICNPLL YTVTMSCQVC LLLLLGAYGM GFAGAMAHTG SIMNLTFCAD NLVNHFMCDI
   181  LPLLELSCNS SYMNELVVFI VVAVDVGMPI VTVFISYALI LSSILHNSST EGRSKAFSTC
   241  SSHIIVVSLF FGSGAFMYLK PLSILPLEQG KVSSLFYTII VPVLNPLIYS LRNKDVKVAL
   301  RRTLGRKIFS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against OR8B12 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 7
Mean surface accessibility (rSASA): 0.27
Highest tissue expression: 0.5 nTPM

Expression across tissuesHPA

Tissue

testis: 0.5 nTPM
adipose tissue: 0 nTPM
adrenal gland: 0 nTPM
amygdala: 0 nTPM
appendix: 0 nTPM
basal ganglia: 0 nTPM

Single-cell type

platelets: 5.6 nCPM
hofbauer cells: 0.3 nCPM
late spermatids: 0.2 nCPM
mast cells: 0.2 nCPM
early spermatids: 0.1 nCPM
leydig cells: 0.1 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebral cortex: 1.2 nTPM
hypothalamus: 0.9 nTPM
basal ganglia: 0.5 nTPM
white matter: 0.3 nTPM
midbrain: 0.2 nTPM
thalamus: 0.2 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.3
gnomAD pLI: 0.26
gnomAD missense Z: 0.2
DepMap mean gene effect: -0.16
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

plasma membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads OR8B12 as an antibody target. Whether an autoantibody or antibody against OR8B12 could matter depends on whether native OR8B12 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

OR8B12 is annotated at the cell surface, where native OR8B12 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label OR8B12 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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