Seroatlas · Human Serome Atlas

OR7G2

Olfactory receptor 7G2

Also known as: OR7G2_HUMAN, OST260

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8NG99
Gene: OR7G2
Ensembl: ENSG00000170923
Chromosome: 19
Canonical length: 324 aa
Protein class: G-protein coupled receptors, Predicted membrane proteins

OverviewNCBI Gene

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

324 residues, UniProt reviewed canonical sequence.

>Q8NG99|OR7G2
     1  MEARNQTAIS KFLLLGLIED PELQPVLFSL FLSMYLVTIL GNLLILLAVI SDSHLHTPMY
    61  FFLSNLSFLD ICLSTTTIPK MLVNIQAQNR SITYSGCLTQ ICFVLFFAGL ENCLLAAMAY
   121  DRYVAICHPL RYTVIMNPRL CGLLILLSLL TSVVNALLLS LMVLRLSFCT DLEIPLFFCE
   181  LAQVIQLTCS DTLINNILIY FAACIFGGVP LSGIILSYTQ ITSCVLRMPS ASGKHKAVST
   241  CGSHLSIVLL FYGAGLGVYI SSVVTDSPRK TAVASVMYSV FPQMVNPFIY SLRNKDMKGT
   301  LRKFIGRIPS LLWCAICFGF RFLE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against OR7G2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 7
Mean surface accessibility (rSASA): 0.3
Highest tissue expression: 0.2 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 0.2 nTPM
skin: 0.2 nTPM
esophagus: 0.1 nTPM
retina: 0.1 nTPM
salivary gland: 0.1 nTPM
skeletal muscle: 0.1 nTPM

Single-cell type

foveolar cells: 0.6 nCPM
migrating cytotrophoblasts: 0.2 nCPM
papillary tip epithelial cells: 0.2 nCPM
cytotrophoblasts: 0.1 nCPM
distal convoluted tubule cells: 0.1 nCPM
fallopian tube ciliated cells: 0.1 nCPM

Immune cell

basophil: 1.5 nTPM
neutrophil: 1.3 nTPM
NK-cell: 0.4 nTPM
memory B-cell: 0.3 nTPM
naive B-cell: 0.3 nTPM
classical monocyte: 0.2 nTPM

Brain region

cerebellum: 3.9 nTPM
white matter: 3.5 nTPM
choroid plexus: 3.3 nTPM
cerebral cortex: 3.1 nTPM
hippocampal formation: 3 nTPM
amygdala: 2.9 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD missense Z: 0.11
DepMap mean gene effect: -0.31
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 1% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

signal transduction

Molecular functions

Cellular components

plasma membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads OR7G2 as an antibody target. Whether an autoantibody or antibody against OR7G2 could matter depends on whether native OR7G2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

OR7G2 is annotated at the cell surface, where native OR7G2 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label OR7G2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...