Seroatlas · Human Serome Atlas

OR7E24

Olfactory receptor 7E24

Also known as: HSHT2, O7E24_HUMAN, OR19-8, OR7E24P, OR7E24Q

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6IFN5
Gene: OR7E24
Ensembl: ENSG00000237521
Chromosome: 19
Canonical length: 339 aa
Protein class: G-protein coupled receptors, Predicted membrane proteins

OverviewNCBI Gene

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

339 residues, UniProt reviewed canonical sequence.

>Q6IFN5|OR7E24
     1  MSYFPILFFF FLKRCPSYTE PQNLTGVSEF LLLGLSEDPE LQPVLAGLFL SMYLVTVLGN
    61  LLIILAVSSD SHLHTPMYFF LSNLSLADIG FTSTTVPKMI VDMQTHSRVI SYEGCLTQMS
   121  FFVLFACMDD MLLSVMAYDR FVAICHPLHY RIIMNPRLCG FLILLSFFIS LLDSQLHNLI
   181  MLQLTCFKDV DISNFFCDPS QLLHLRCSDT FINEMVIYFM GAIFGCLPIS GILFSYYKIV
   241  SPILRVPTSD GKYKAFSTCG SHLAVVCLFY GTGLVGYLSS AVLPSPRKSM VASVMYTVVT
   301  PMLNPFIYSL RNKDIQSALC RLHGRIIKSH HLHPFCYMG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against OR7E24 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 7
Mean surface accessibility (rSASA): 0.3
Highest tissue expression: 1.5 nTPM

Expression across tissuesHPA

Tissue

testis: 1.5 nTPM
ovary: 0.1 nTPM
adipose tissue: 0 nTPM
adrenal gland: 0 nTPM
amygdala: 0 nTPM
appendix: 0 nTPM

Single-cell type

oocytes: 65 nCPM
early spermatids: 15 nCPM
late primary spermatocytes: 11 nCPM
late spermatids: 6.7 nCPM
gastric chief cells: 1.1 nCPM
sertoli cells: 1.1 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

choroid plexus: 0.1 nTPM
midbrain: 0.1 nTPM
amygdala: 0 nTPM
basal ganglia: 0 nTPM
cerebellum: 0 nTPM
cerebral cortex: 0 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD missense Z: 0.11
DepMap mean gene effect: -0.15
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

signal transduction

Molecular functions

Cellular components

plasma membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads OR7E24 as an antibody target. Whether an autoantibody or antibody against OR7E24 could matter depends on whether native OR7E24 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

OR7E24 is annotated at the cell surface, where native OR7E24 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label OR7E24 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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