Seroatlas · Human Serome Atlas

OR7D4

Olfactory receptor 7D4

Also known as: hg105, OR19-B, OR7D4_HUMAN, OR7D4P

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8NG98
Gene: OR7D4
Ensembl: ENSG00000174667
Chromosome: 19
Canonical length: 312 aa
Protein class: G-protein coupled receptors, Predicted membrane proteins

OverviewNCBI Gene

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

312 residues, UniProt reviewed canonical sequence.

>Q8NG98|OR7D4
     1  MEAENLTELS KFLLLGLSDD PELQPVLFGL FLSMYLVTVL GNLLIILAVS SDSHLHTPMY
    61  FFLSNLSFVD ICFISTTVPK MLVSIQARSK DISYMGCLTQ VYFLMMFAGM DTFLLAVMAY
   121  DRFVAICHPL HYTVIMNPCL CGLLVLASWF IIFWFSLVHI LLMKRLTFST GTEIPHFFCE
   181  PAQVLKVACS NTLLNNIVLY VATALLGVFP VAGILFSYSQ IVSSLMGMSS TKGKYKAFST
   241  CGSHLCVVSL FYGTGLGVYL SSAVTHSSQS SSTASVMYAM VTPMLNPFIY SLRNKDVKGA
   301  LERLLSRADS CP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against OR7D4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 7
Mean surface accessibility (rSASA): 0.28
Highest tissue expression: 0.3 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 0.3 nTPM
retina: 0.2 nTPM
cerebral cortex: 0.1 nTPM
epididymis: 0.1 nTPM
skeletal muscle: 0.1 nTPM
skin: 0.1 nTPM

Single-cell type

late spermatids: 0.9 nCPM
late primary spermatocytes: 0.6 nCPM
early spermatids: 0.4 nCPM
mesothelial cells: 0.4 nCPM
cdc: 0.3 nCPM
distal convoluted tubule cells: 0.3 nCPM

Immune cell

basophil: 1.3 nTPM
neutrophil: 0.6 nTPM
NK-cell: 0.2 nTPM
classical monocyte: 0.1 nTPM
eosinophil: 0.1 nTPM
memory B-cell: 0.1 nTPM

Brain region

cerebellum: 4.7 nTPM
white matter: 4.1 nTPM
amygdala: 3.7 nTPM
cerebral cortex: 3.6 nTPM
choroid plexus: 3.4 nTPM
basal ganglia: 3.3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.93
gnomAD pLI: 0.02
gnomAD missense Z: -0.49
DepMap mean gene effect: -0.18
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

signal transduction

Molecular functions

Cellular components

plasma membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads OR7D4 as an antibody target. Whether an autoantibody or antibody against OR7D4 could matter depends on whether native OR7D4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

OR7D4 is annotated at the cell surface, where native OR7D4 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label OR7D4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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