Seroatlas · Human Serome Atlas

OR7D2

Olfactory receptor 7D2

Also known as: FLJ38149, HTPCRH03, OR19-4, OR7D2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96RA2
Gene: OR7D2
Ensembl: ENSG00000188000
Chromosome: 19
Canonical length: 312 aa
Protein class: G-protein coupled receptors, Predicted membrane proteins

OverviewNCBI Gene

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

312 residues, UniProt reviewed canonical sequence.

>Q96RA2|OR7D2
     1  MEAGNQTGFL EFILLGLSED PELQPFIFGL FLSMYLVTVL GNLLIILAIS SDSHLHTPMY
    61  FFLSNLSWVD ICFSTCIVPK MLVNIQTENK AISYMDCLTQ VYFSMFFPIL DTLLLTVMAY
   121  DRFVAVCHPL HYMIIMNPHL CGLLVFVTWL IGVMTSLLHI SLMMHLIFCK DFEIPHFFCE
   181  LTYILQLACS DTFLNSTLIY FMTGVLGVFP LLGIIFSYSR IASSIRKMSS SGGKQKALST
   241  CGSHLSVVSL FYGTGIGVHF TSAVTHSSQK ISVASVMYTV VTPMLNPFIY SLRNKDVKGA
   301  LGSLLSRAAS CL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against OR7D2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 7
Mean surface accessibility (rSASA): 0.28
Highest tissue expression: 1.1 nTPM

Expression across tissuesHPA

Tissue

testis: 1.1 nTPM
bone marrow: 0.7 nTPM
lymph node: 0.5 nTPM
retina: 0.5 nTPM
cerebral cortex: 0.4 nTPM
choroid plexus: 0.4 nTPM

Single-cell type

early spermatids: 17 nCPM
late primary spermatocytes: 7.2 nCPM
choroid plexus epithelial cells: 2.9 nCPM
astrocytes: 2.3 nCPM
oligodendrocytes: 1.8 nCPM
late spermatids: 1.7 nCPM

Immune cell

basophil: 0.5 nTPM
neutrophil: 0.5 nTPM
NK-cell: 0.2 nTPM
plasmacytoid DC: 0.2 nTPM
classical monocyte: 0.1 nTPM
eosinophil: 0.1 nTPM

Brain region

cerebellum: 5.8 nTPM
white matter: 5.5 nTPM
cerebral cortex: 5.3 nTPM
amygdala: 4.8 nTPM
hypothalamus: 4.8 nTPM
basal ganglia: 4.6 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD missense Z: 0.15
DepMap mean gene effect: -0.03
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

plasma membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads OR7D2 as an antibody target. Whether an autoantibody or antibody against OR7D2 could matter depends on whether native OR7D2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

OR7D2 is annotated at the cell surface, where native OR7D2 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label OR7D2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...