Seroatlas · Human Serome Atlas

OR7C1

Olfactory receptor 7C1

Also known as: OR19-5, OR7C1_HUMAN, OR7C4

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O76099
Gene: OR7C1
Ensembl: ENSG00000127530
Chromosome: 19
Canonical length: 320 aa
Protein class: G-protein coupled receptors, Predicted membrane proteins

OverviewNCBI Gene

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

320 residues, UniProt reviewed canonical sequence.

>O76099|OR7C1
     1  METGNQTHAQ EFLLLGFSAT SEIQFILFGL FLSMYLVTFT GNLLIILAIC SDSHLHTPMY
    61  FFLSNLSFAD LCFTSTTVPK MLLNILTQNK FITYAGCLSQ IFFFTSFGCL DNLLLTVMAY
   121  DRFVAVCHPL HYTVIMNPQL CGLLVLGSWC ISVMGSLLET LTVLRLSFCT EMEIPHFFCD
   181  LLEVLKLACS DTFINNVVIY FATGVLGVIS FTGIFFSYYK IVFSILRISS AGRKHKAFST
   241  CGSHLSVVTL FYGTGFGVYL SSAATPSSRT SLVASVMYTM VTPMLNPFIY SLRNTDMKRA
   301  LGRLLSRATF FNGDITAGLS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against OR7C1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 7
Mean surface accessibility (rSASA): 0.29
Highest tissue expression: 6.4 nTPM

Expression across tissuesHPA

Tissue

parathyroid gland: 6.4 nTPM
epididymis: 2.3 nTPM
testis: 1.8 nTPM
pituitary gland: 1.7 nTPM
skeletal muscle: 1.7 nTPM
prostate: 0.8 nTPM

Single-cell type

melanocytes: 44 nCPM
somatotrophs: 29 nCPM
basal prostatic cells: 29 nCPM
sertoli cells: 21 nCPM
prostatic glandular cells: 16 nCPM
tuft cells: 12 nCPM

Immune cell

neutrophil: 3.2 nTPM
basophil: 1.4 nTPM
eosinophil: 0.9 nTPM
classical monocyte: 0.7 nTPM
non-classical monocyte: 0.6 nTPM
intermediate monocyte: 0.4 nTPM

Brain region

cerebral cortex: 9.1 nTPM
white matter: 9.1 nTPM
pons: 7.5 nTPM
basal ganglia: 7.1 nTPM
amygdala: 7 nTPM
medulla oblongata: 7 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD missense Z: 0.68
DepMap mean gene effect: -0.15
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

plasma membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads OR7C1 as an antibody target. Whether an autoantibody or antibody against OR7C1 could matter depends on whether native OR7C1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

OR7C1 is annotated at the cell surface, where native OR7C1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label OR7C1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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