Seroatlas · Human Serome Atlas

OR7A5

Olfactory receptor 7A5

Also known as: HTPCR2, OR7A5_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q15622
Gene: OR7A5
Ensembl: ENSG00000188269
Chromosome: 19
Canonical length: 319 aa
Protein class: G-protein coupled receptors, Predicted membrane proteins

OverviewNCBI Gene

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

319 residues, UniProt reviewed canonical sequence.

>Q15622|OR7A5
     1  MEPGNDTQIS EFLLLGFSQE PGLQPFLFGL FLSMYLVTVL GNLLIILATI SDSHLHTPMY
    61  FFLSNLSFAD ICVTSTTIPK MLMNIQTQNK VITYIACLMQ MYFFILFAGF ENFLLSVMAY
   121  DRFVAICHPL HYMVIMNPHL CGLLVLASWT MSALYSLLQI LMVVRLSFCT ALEIPHFFCE
   181  LNQVIQLACS DSFLNHMVIY FTVALLGGGP LTGILYSYSK IISSIHAISS AQGKYKAFST
   241  CASHLSVVSL FYGAILGVYL SSAATRNSHS SATASVMYTV VTPMLNPFIY SLRNKDIKRA
   301  LGIHLLWGTM KGQFFKKCP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against OR7A5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 7
Mean surface accessibility (rSASA): 0.29
Highest tissue expression: 6.6 nTPM

Expression across tissuesHPA

Tissue

parathyroid gland: 6.6 nTPM
epididymis: 4.2 nTPM
spinal cord: 2.6 nTPM
midbrain: 2.5 nTPM
pituitary gland: 1.7 nTPM
hippocampal formation: 1.4 nTPM

Single-cell type

oligodendrocytes: 0.1 nCPM
prostatic glandular cells: 0.1 nCPM
somatotrophs: 0.1 nCPM
adipocytes: 0 nCPM
adrenal cortex cells: 0 nCPM
adrenal medulla cells: 0 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

white matter: 6.8 nTPM
pons: 5.2 nTPM
medulla oblongata: 4.7 nTPM
cerebellum: 4.3 nTPM
basal ganglia: 4.2 nTPM
thalamus: 3.8 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD missense Z: 0.15
DepMap mean gene effect: 0.06
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads OR7A5 as an antibody target. Whether an autoantibody or antibody against OR7A5 could matter depends on whether native OR7A5 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

OR7A5 is annotated at the cell surface, where native OR7A5 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label OR7A5 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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