Seroatlas · Human Serome Atlas

OR7A17

Olfactory receptor 7A17

Also known as: HTPCRX19, OR7AH_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O14581
Gene: OR7A17
Ensembl: ENSG00000185385
Chromosome: 19
Canonical length: 309 aa
Protein class: G-protein coupled receptors, Predicted membrane proteins

OverviewNCBI Gene

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

309 residues, UniProt reviewed canonical sequence.

>O14581|OR7A17
     1  MEPENDTGIS EFVLLGLSEE PELQPFLFGL FLSMYLVTVL GNLLIILATI SDSHLHTPMY
    61  FFLSNLSFAD ICFISTTIPK MLINIQTQSR VITYAGCITQ MCFFVLFGGL DSLLLAVMAY
   121  DRFVAICHPL HYTVIMNPRL CGLLVLASWM IAALNSLSQS LMVLWLSFCT DLEIPHFFCE
   181  LNQVIHLACS DTFLNDMGMY FAAGLLAGGP LVGILCSYSK IVSSIRAISS AQGKYKAFST
   241  CASHLSVVSL FCCTGLGVYL TSAATHNSHT SATASVMYTV ATPMLNPFIY SLRNKDIKRA
   301  LKMSFRGKQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against OR7A17 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 7
Mean surface accessibility (rSASA): 0.28
Highest tissue expression: 0.3 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 0.3 nTPM
appendix: 0.2 nTPM
epididymis: 0.2 nTPM
skin: 0.2 nTPM
adrenal gland: 0.1 nTPM
cerebral cortex: 0.1 nTPM

Single-cell type

sertoli cells: 2.2 nCPM
retinal bipolar cells: 1.7 nCPM
basal prostatic cells: 0.6 nCPM
early spermatids: 0.4 nCPM
nk-cells: 0.3 nCPM
podocytes: 0.3 nCPM

Immune cell

basophil: 0.6 nTPM
neutrophil: 0.6 nTPM
naive B-cell: 0.2 nTPM
NK-cell: 0.2 nTPM
classical monocyte: 0.1 nTPM
eosinophil: 0.1 nTPM

Brain region

cerebellum: 4.5 nTPM
cerebral cortex: 4.4 nTPM
thalamus: 4.4 nTPM
white matter: 4.4 nTPM
hypothalamus: 4.3 nTPM
midbrain: 4.3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.86
gnomAD pLI: 0.32
gnomAD missense Z: -1.02
DepMap mean gene effect: -0.45
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 1% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

signal transduction

Molecular functions

Cellular components

plasma membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads OR7A17 as an antibody target. Whether an autoantibody or antibody against OR7A17 could matter depends on whether native OR7A17 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

OR7A17 is annotated at the cell surface, where native OR7A17 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label OR7A17 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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