Seroatlas · Human Serome Atlas

OR6Y1

Olfactory receptor 6Y1

Also known as: OR6Y1_HUMAN, OR6Y2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8NGX8
Gene: OR6Y1
Ensembl: ENSG00000197532
Chromosome: 1
Canonical length: 325 aa
Protein class: G-protein coupled receptors, Predicted membrane proteins

OverviewNCBI Gene

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

325 residues, UniProt reviewed canonical sequence.

>Q8NGX8|OR6Y1
     1  MTTIILEVDN HTVTTRFILL GFPTRPAFQL LFFSIFLATY LLTLLENLLI ILAIHSDGQL
    61  HKPMYFFLSH LSFLEMWYVT VISPKMLVDF LSHDKSISFN GCMTQLYFFV TFVCTEYILL
   121  AIMAFDRYVA ICNPLRYPVI MTNQLCGTLA GGCWFCGLMT AMIKMVFIAQ LHYCGMPQIN
   181  HYFCDISPLL NVSCEDASQA EMVDFFLALM VIAIPLCVVV ASYAAILATI LRIPSAQGRQ
   241  KAFSTCASHL TVVILFYSMT LFTYARPKLM YAYNSNKVVS VLYTVIVPLL NPIIYCLRNH
   301  EVKAALRKTI HCRGSGPQGN GAFSS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against OR6Y1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 7
Mean surface accessibility (rSASA): 0.29
Highest tissue expression: 1.2 nTPM

Expression across tissuesHPA

Tissue

retina: 1.2 nTPM
bone marrow: 1 nTPM
skin: 0.9 nTPM
epididymis: 0.4 nTPM
salivary gland: 0.4 nTPM
stomach: 0.4 nTPM

Single-cell type

pericytes: 0.9 nCPM
vascular smooth muscle cells: 0.6 nCPM
late primary spermatocytes: 0.2 nCPM
colonocytes: 0.1 nCPM
early spermatids: 0.1 nCPM
nk-cells: 0.1 nCPM

Immune cell

basophil: 0.4 nTPM
eosinophil: 0.1 nTPM
naive B-cell: 0.1 nTPM
neutrophil: 0.1 nTPM
non-classical monocyte: 0.1 nTPM
classical monocyte: 0 nTPM

Brain region

cerebellum: 18 nTPM
cerebral cortex: 18 nTPM
basal ganglia: 15 nTPM
white matter: 15 nTPM
amygdala: 15 nTPM
hypothalamus: 15 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.59
gnomAD pLI: 0
gnomAD missense Z: -0.97
DepMap mean gene effect: -0.03
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 1% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

detection of chemical stimulus involved in sensory perception of smell

Molecular functions

Cellular components

plasma membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads OR6Y1 as an antibody target. Whether an autoantibody or antibody against OR6Y1 could matter depends on whether native OR6Y1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

OR6Y1 is annotated at the cell surface, where native OR6Y1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label OR6Y1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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