Seroatlas · Human Serome Atlas

OR6M1

Olfactory receptor 6M1

Also known as: OR6M1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8NGM8
Gene: OR6M1
Ensembl: ENSG00000196099
Chromosome: 11
Canonical length: 313 aa
Protein class: G-protein coupled receptors, Predicted membrane proteins

OverviewNCBI Gene

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

313 residues, UniProt reviewed canonical sequence.

>Q8NGM8|OR6M1
     1  MGNWSTVTEI TLIAFPALLE IRISLFVVLV VTYTLTATGN ITIISLIWID HRLQTPMYFF
    61  LSNLSFLDIL YTTVITPKLL ACLLGEEKTI SFAGCMIQTY FYFFLGTVEF ILLAVMSFDR
   121  YMAICDPLHY TVIMNSRACL LLVLGCWVGA FLSVLFPTIV VTRLPYCRKE INHFFCDIAP
   181  LLQVACINTH LIEKINFLLS ALVILSSLAF TTGSYVYIIS TILRIPSTQG RQKAFSTCAS
   241  HITVVSIAHG SNIFVYVRPN QNSSLDYDKV AAVLITVVTP LLNPFIYSLR NEKVQEVLRE
   301  TVNRIMTLIQ RKT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against OR6M1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 7
Mean surface accessibility (rSASA): 0.27
Highest tissue expression: 0.5 nTPM

Expression across tissuesHPA

Tissue

pancreas: 0.5 nTPM
testis: 0.2 nTPM
adipose tissue: 0 nTPM
adrenal gland: 0 nTPM
amygdala: 0 nTPM
appendix: 0 nTPM

Single-cell type

early spermatids: 1.6 nCPM
late spermatids: 0.3 nCPM
vascular endothelial cells: 0.2 nCPM
late primary spermatocytes: 0.1 nCPM
mast cells: 0.1 nCPM
pericytes: 0.1 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

hypothalamus: 0.2 nTPM
amygdala: 0.1 nTPM
basal ganglia: 0.1 nTPM
cerebral cortex: 0.1 nTPM
hippocampal formation: 0.1 nTPM
medulla oblongata: 0.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.8
gnomAD pLI: 0
gnomAD missense Z: 0.16
DepMap mean gene effect: -0.01
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

Cellular components

plasma membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads OR6M1 as an antibody target. Whether an autoantibody or antibody against OR6M1 could matter depends on whether native OR6M1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

OR6M1 is annotated at the cell surface, where native OR6M1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label OR6M1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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