Seroatlas · Human Serome Atlas

OR6J1

Olfactory receptor 6J1

Also known as: OR6J1_HUMAN, OR6J1P, OR6J2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8NGC5
Gene: OR6J1
Ensembl: ENSG00000255804
Chromosome: 14
Canonical length: 347 aa
Protein class: G-protein coupled receptors, Predicted membrane proteins

OverviewNCBI Gene

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. This olfactory receptor gene is a segregating pseudogene, where some individuals have an allele that encodes a functional olfactory receptor, while other individuals have an allele encoding a protein that is predicted to be non-functional. [provided by RefSeq, Jan 2017]

Canonical amino-acid sequenceUniProt

347 residues, UniProt reviewed canonical sequence.

>Q8NGC5|OR6J1
     1  MGNWTAAVTE FVLLGFSLSR EVELLLLVLL LPTFLLTLLG NLLIISTVLS CSRLHTPMYF
    61  FLCNLSILDI LFTSVISPKV LANLGSRDKT ISFAGCITQC YFYFFLGTVE FLLLTVMSYD
   121  RYATICCPLR YTTIMRPSVC IGTVVFSWVG GFLSVLFPTI LISQLPFCGS NIINHFFCDS
   181  GPLLALACAD TTAIELMDFM LSSMVILCCI VLVAYSYTYI ILTIVRIPSA SGRKKAFNTC
   241  ASHLTIVIIS SGITVFIYVT PSQKEYLEIN KIPLVLSSVV TPFLNPFIYT LRNDTVQGVL
   301  RDVWVRVRGV FEKRMRAVLR SRLSSNKDHQ GRACSSPPCV YSVKLQC

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against OR6J1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 7
Mean surface accessibility (rSASA): 0.3
Highest tissue expression: 0.6 nTPM

Expression across tissuesHPA

Tissue

retina: 0.6 nTPM
bone marrow: 0.4 nTPM
skin: 0.3 nTPM
appendix: 0.2 nTPM
epididymis: 0.2 nTPM
pancreas: 0.2 nTPM

Single-cell type

cone photoreceptor cells: 33 nCPM
rod photoreceptor cells: 4.9 nCPM
bergmann glia: 1.9 nCPM
astrocytes: 1.7 nCPM
ependymal cells: 1.6 nCPM
distal convoluted tubule cells: 1.4 nCPM

Immune cell

basophil: 0.7 nTPM
neutrophil: 0.4 nTPM
eosinophil: 0.1 nTPM
naive B-cell: 0.1 nTPM
naive CD8 T-cell: 0.1 nTPM
NK-cell: 0.1 nTPM

Brain region

cerebellum: 4.3 nTPM
white matter: 3.7 nTPM
cerebral cortex: 3.5 nTPM
hippocampal formation: 3.4 nTPM
basal ganglia: 3.2 nTPM
amygdala: 3.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.65
gnomAD pLI: 0.05
gnomAD missense Z: 0.99

OntologyGO

Molecular functions

Cellular components

plasma membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads OR6J1 as an antibody target. Whether an autoantibody or antibody against OR6J1 could matter depends on whether native OR6J1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

OR6J1 is annotated at the cell surface, where native OR6J1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label OR6J1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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