Seroatlas · Human Serome Atlas

OR6F1

Olfactory receptor 6F1

Also known as: OR6F1_HUMAN, OST731

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8NGZ6
Gene: OR6F1
Ensembl: ENSG00000169214
Chromosome: 1
Canonical length: 308 aa
Protein class: G-protein coupled receptors, Predicted membrane proteins

OverviewNCBI Gene

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

308 residues, UniProt reviewed canonical sequence.

>Q8NGZ6|OR6F1
     1  MDTGNKTLPQ DFLLLGFPGS QTLQLSLFML FLVMYILTVS GNVAILMLVS TSHQLHTPMY
    61  FFLSNLSFLE IWYTTAAVPK ALAILLGRSQ TISFTSCLLQ MYFVFSLGCT EYFLLAAMAY
   121  DRCLAICYPL HYGAIMSSLL SAQLALGSWV CGFVAIAVPT ALISGLSFCG PRAINHFFCD
   181  IAPWIALACT NTQAVELVAF VIAVVVILSS CLITFVSYVY IISTILRIPS ASGRSKAFST
   241  CSSHLTVVLI WYGSTVFLHV RTSIKDALDL IKAVHVLNTV VTPVLNPFIY TLRNKEVRET
   301  LLKKWKGK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against OR6F1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 7
Mean surface accessibility (rSASA): 0.28
Highest tissue expression: 0.6 nTPM

Expression across tissuesHPA

Tissue

testis: 0.6 nTPM
adipose tissue: 0 nTPM
adrenal gland: 0 nTPM
amygdala: 0 nTPM
appendix: 0 nTPM
basal ganglia: 0 nTPM

Single-cell type

late primary spermatocytes: 9.7 nCPM
early spermatids: 5.5 nCPM
late spermatids: 1 nCPM
early primary spermatocytes: 0.1 nCPM
mast cells: 0.1 nCPM
müller glia: 0.1 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

pons: 0.6 nTPM
medulla oblongata: 0.5 nTPM
cerebral cortex: 0.4 nTPM
hypothalamus: 0.4 nTPM
white matter: 0.3 nTPM
amygdala: 0.2 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.93
gnomAD pLI: 0
gnomAD missense Z: 0.34
DepMap mean gene effect: -0.02
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

Cellular components

plasma membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads OR6F1 as an antibody target. Whether an autoantibody or antibody against OR6F1 could matter depends on whether native OR6F1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

OR6F1 is annotated at the cell surface, where native OR6F1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label OR6F1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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