Seroatlas · Human Serome Atlas

OR6C75

Olfactory receptor 6C75

Also known as: O6C75_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: A6NL08
Gene: OR6C75
Ensembl: ENSG00000187857
Chromosome: 12
Canonical length: 312 aa
Protein class: G-protein coupled receptors, Predicted membrane proteins

OverviewNCBI Gene

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

312 residues, UniProt reviewed canonical sequence.

>A6NL08|OR6C75
     1  MRNSTAVTDF ILLGLTSDPQ WQVVLFIFLL VTYMLSVTGN LIIITLTLSD PHLQTPMYFF
    61  LRNFSFLEIS FTSVCIPRFL VTVVTGNRTI SYNGCVAQLF FFIFLGVTEF YLLAAMSYDR
   121  CMAICKPLHY TIIMSTRVCT LLVFSSWLAG FLIIFPPVML LLQLDFCASN VIDHFICDSS
   181  PMLQLSCTNT HFLELMAFFL AVVTLMVTLT LVILSYTNII RTILKIPSMS QRKKAFSTCS
   241  SHMIVVSISY SSCIFMYIKT SARERVTLSK GVAVLNTSVA PLLNPFIYTL RNKQVKQAFK
   301  SMVQKMIFSL NK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against OR6C75 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 7
Mean surface accessibility (rSASA): 0.28
Highest tissue expression: 0 nTPM

Expression across tissuesHPA

Tissue

adipose tissue: 0 nTPM
adrenal gland: 0 nTPM
amygdala: 0 nTPM
appendix: 0 nTPM
basal ganglia: 0 nTPM
blood vessel: 0 nTPM

Single-cell type

early primary spermatocytes: 0.1 nCPM
gonadotrophs: 0.1 nCPM
pancreatic islet cells: 0.1 nCPM
pericytes: 0.1 nCPM
undifferentiated spermatogonia: 0.1 nCPM
adipocytes: 0 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

amygdala: 0 nTPM
basal ganglia: 0 nTPM
cerebellum: 0 nTPM
cerebral cortex: 0 nTPM
choroid plexus: 0 nTPM
hippocampal formation: 0 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.51
gnomAD pLI: 0.02
gnomAD missense Z: -0.07
DepMap mean gene effect: -0.04
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

Cellular components

plasma membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads OR6C75 as an antibody target. Whether an autoantibody or antibody against OR6C75 could matter depends on whether native OR6C75 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

OR6C75 is annotated at the cell surface, where native OR6C75 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label OR6C75 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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