Seroatlas · Human Serome Atlas

OR6C2

Olfactory receptor 6C2

Also known as: OR6C2_HUMAN, OR6C67

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9NZP2
Gene: OR6C2
Ensembl: ENSG00000179695
Chromosome: 12
Canonical length: 312 aa
Protein class: G-protein coupled receptors, Predicted membrane proteins

OverviewNCBI Gene

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

312 residues, UniProt reviewed canonical sequence.

>Q9NZP2|OR6C2
     1  MKNHTVIRTF ILLGLTGDPH LQVLLFIFLF LTYMLSVTGN LTIITLTLVD HHLKTPMYFF
    61  LRNFSFLEVS FTTVCIPRFL YNISMGDNTI TYNACASQIF FVILFGATEF FLLAAMSYDR
   121  YVAICKPLHY VVIMNNRVCT LLVLCCWVAG LMIIVPPLSL GLQLEFCDSN AIDHFSCDAG
   181  PLLKISCSDT WVIEQMVILM AVFALIITLV CVILSYLYIV RTILKFPSVQ QRKKAFSTCS
   241  SHMIVVSIAY GSCIFIYIKP SAKDEVAINK GVSVLTTSVA PLLNPFIYTL RNKQVKQAFS
   301  DSIKRIAFLS KK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against OR6C2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 7
Mean surface accessibility (rSASA): 0.28
Highest tissue expression: 0.1 nTPM

Expression across tissuesHPA

Tissue

epididymis: 0.1 nTPM
adipose tissue: 0 nTPM
adrenal gland: 0 nTPM
amygdala: 0 nTPM
appendix: 0 nTPM
basal ganglia: 0 nTPM

Single-cell type

cardiomyocytes: 2.6 nCPM
papillary tip epithelial cells: 2 nCPM
parietal cells: 1.8 nCPM
breast lactating cells: 1.7 nCPM
esophageal apical cells: 1.5 nCPM
gastric progenitor cells: 1.3 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

basal ganglia: 0.1 nTPM
pons: 0.1 nTPM
white matter: 0.1 nTPM
amygdala: 0 nTPM
cerebellum: 0 nTPM
cerebral cortex: 0 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.32
gnomAD pLI: 0.09
gnomAD missense Z: -1.23
DepMap mean gene effect: -0.1
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

sensory perception of smell

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads OR6C2 as an antibody target. Whether an autoantibody or antibody against OR6C2 could matter depends on whether native OR6C2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

OR6C2 is annotated at the cell surface, where native OR6C2 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label OR6C2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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