OR6B2
Olfactory receptor 6B2
Also known as: OR6B2_HUMAN, OR6B2P
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q6IFH4
- Gene
- OR6B2
- Ensembl
- ENSG00000182083
- Chromosome
- 2
- Canonical length
- 312 aa
- Protein class
- G-protein coupled receptors, Predicted membrane proteins
- Subcellular location
- Plasma membrane,Cytosol
OverviewNCBI Gene
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]
Canonical amino-acid sequenceUniProt
312 residues, UniProt reviewed canonical sequence.
>Q6IFH4|OR6B2
1 MSGENVTKVS TFILVGLPTA PGLQYLLFLL FLLTYLFVLV ENLAIILIVW SSTSLHRPMY
61 YFLSSMSFLE IWYVSDITPK MLEGFLLQQK RISFVGCMTQ LYFFSSLVCT ECVLLASMAY
121 DRYVAICHPL RYHVLVTPGL CLQLVGFSFV SGFTISMIKV CFISSVTFCG SNVLNHFFCD
181 ISPILKLACT DFSTAELVDF ILAFIILVFP LLATILSYWH ITLAVLRIPS ATGCWRAFST
241 CASHLTVVTV FYTALLFMYV RPQAIDSQSS NKLISAVYTV VTPIINPLIY CLRNKEFKDA
301 LKKALGLGQT SHLocalizationUniProt · AlphaFold · HPA
Whether an antibody against OR6B2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Cell surface
- Secreted
- No
- Transmembrane segments
- 7
- Mean surface accessibility (rSASA)
- 0.28
- Highest tissue expression
- 0.3 nTPM
Expression across tissuesHPA
Tissue
- retina: 0.3 nTPM
- testis: 0.3 nTPM
- adipose tissue: 0 nTPM
- adrenal gland: 0 nTPM
- appendix: 0 nTPM
- bone marrow: 0 nTPM
Single-cell type
- late spermatids: 0.3 nCPM
- adipocytes: 0 nCPM
- adrenal cortex cells: 0 nCPM
- adrenal medulla cells: 0 nCPM
- alveolar cells type 1: 0 nCPM
- alveolar cells type 2: 0 nCPM
Immune cell
- basophil: 0 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
- gdT-cell: 0 nTPM
- intermediate monocyte: 0 nTPM
- MAIT T-cell: 0 nTPM
Brain region
- pons: 0.2 nTPM
- amygdala: 0.1 nTPM
- cerebral cortex: 0.1 nTPM
- hippocampal formation: 0.1 nTPM
- medulla oblongata: 0.1 nTPM
- midbrain: 0.1 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.44
- gnomAD pLI
- 0.02
- gnomAD missense Z
- -0.33
- DepMap mean gene effect
- -0.05
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads OR6B2 as an antibody target. Whether an autoantibody or antibody against OR6B2 could matter depends on whether native OR6B2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
OR6B2 is annotated at the cell surface, where native OR6B2 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.
Annotation status
The present source text does not explicitly label OR6B2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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