Seroatlas · Human Serome Atlas

OR5V1

Olfactory receptor 5V1

Also known as: hs6M1-21, OR5V1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9UGF6
Gene: OR5V1
Ensembl: ENSG00000243729
Chromosome: 6
Canonical length: 321 aa
Protein class: G-protein coupled receptors, Predicted membrane proteins

OverviewNCBI Gene

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

321 residues, UniProt reviewed canonical sequence.

>Q9UGF6|OR5V1
     1  MERKNQTAIT EFIILGFSNL NELQFLLFTI FFLTYFCTLG GNILIILTTV TDPHLHTPMY
    61  YFLGNLAFID ICYTTSNVPQ MMVHLLSKKK SISYVGCVVQ LFAFVFFVGS ECLLLAAMAY
   121  DRYIAICNPL RYSVILSKVL CNQLAASCWA AGFLNSVVHT VLTFCLPFCG NNQINYFFCD
   181  IPPLLILSCG NTSVNELALL STGVFIGWTP FLCIVLSYIC IISTILRIQS SEGRRKAFST
   241  CASHLAIVFL FYGSAIFTYV RPISTYSLKK DRLVSVLYSV VTPMLNPIIY TLRNKDIKEA
   301  VKTIGSKWQP PISSLDSKLT Y

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against OR5V1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 7
Mean surface accessibility (rSASA): 0.28
Highest tissue expression: 0.2 nTPM

Expression across tissuesHPA

Tissue

testis: 0.2 nTPM
adipose tissue: 0 nTPM
adrenal gland: 0 nTPM
amygdala: 0 nTPM
appendix: 0 nTPM
basal ganglia: 0 nTPM

Single-cell type

ependymal cells: 56 nCPM
late spermatids: 2 nCPM
early spermatids: 1.8 nCPM
brain excitatory neurons: 1.3 nCPM
late primary spermatocytes: 1.1 nCPM
undifferentiated spermatogonia: 0.8 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

midbrain: 1.7 nTPM
medulla oblongata: 1.6 nTPM
spinal cord: 0.9 nTPM
pons: 0.7 nTPM
hippocampal formation: 0.3 nTPM
amygdala: 0.2 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.66
gnomAD pLI: 0.01
gnomAD missense Z: 0.23
DepMap mean gene effect: 0.05
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

detection of chemical stimulus involved in sensory perception of smell

Molecular functions

Cellular components

plasma membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads OR5V1 as an antibody target. Whether an autoantibody or antibody against OR5V1 could matter depends on whether native OR5V1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

OR5V1 is annotated at the cell surface, where native OR5V1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label OR5V1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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