Seroatlas · Human Serome Atlas

OR5T2

Olfactory receptor 5T2

Also known as: OR5T2_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8NGG2
Gene: OR5T2
Canonical length: 359 aa
Protein class: Predicted membrane proteins

OverviewNCBI Gene

No narrative summary is available for OR5T2 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

359 residues, UniProt reviewed canonical sequence.

>Q8NGG2|OR5T2
     1  MSYSIYKSTV NIPLSHGVVH SFCHNMNCNF MHIFKFVLDF NMKNVTEVTL FVLKGFTDNL
    61  ELQTIFFFLF LAIYLFTLMG NLGLILVVIR DSQLHKPMYY FLSMLSSVDA CYSSVITPNM
   121  LVDFTTKNKV ISFLGCVAQV FLACSFGTTE CFLLAAMAYD RYVAIYNPLL YSVSMSPRVY
   181  MPLINASYVA GILHATIHTV ATFSLSFCGA NEIRRVFCDI PPLLAISYSD THTNQLLLFY
   241  FVGSIELVTI LIVLISYGLI LLAILKMYSA EGRRKVFSTC GAHLTGVSIY YGTILFMYVR
   301  PSSSYASDHD MIVSIFYTIV IPLLNPVIYS LRNKDVKDSM KKMFGKNQVI NKVYFHTKK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against OR5T2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 7
Mean surface accessibility (rSASA): 0.29
Highest tissue expression: 0.4 nTPM

Expression across tissuesHPA

Tissue

retina: 0.4 nTPM
skin: 0.1 nTPM
adipose tissue: 0 nTPM
adrenal gland: 0 nTPM
amygdala: 0 nTPM
appendix: 0 nTPM

Single-cell type

adipocytes: 0 nCPM
adrenal cortex cells: 0 nCPM
adrenal medulla cells: 0 nCPM
alveolar cells type 1: 0 nCPM
alveolar cells type 2: 0 nCPM
astrocytes: 0 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebellum: 2.3 nTPM
cerebral cortex: 1.7 nTPM
white matter: 1.5 nTPM
basal ganglia: 1.3 nTPM
hypothalamus: 1.3 nTPM
medulla oblongata: 1.3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.81
gnomAD pLI: 0
gnomAD missense Z: -2.08
DepMap mean gene effect: -0.12
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

plasma membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads OR5T2 as an antibody target. Whether an autoantibody or antibody against OR5T2 could matter depends on whether native OR5T2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

OR5T2 is annotated at the cell surface, where native OR5T2 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label OR5T2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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