OR5M11
Olfactory receptor 5M11
Also known as: OR11-199, OR5MB_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q96RB7
- Gene
- OR5M11
- Ensembl
- ENSG00000255223
- Chromosome
- 11
- Canonical length
- 305 aa
- Protein class
- G-protein coupled receptors, Predicted membrane proteins
OverviewNCBI Gene
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]
Canonical amino-acid sequenceUniProt
305 residues, UniProt reviewed canonical sequence.
>Q96RB7|OR5M11
1 MSNTNGSAIT EFILLGLTDC PELQSLLFVL FLVVYLVTLL GNLGMIMLMR LDSRLHTPMY
61 FFLTNLAFVD LCYTSNATPQ MSTNIVSEKT ISFAGCFTQC YIFIALLLTE FYMLAAMAYD
121 RYVAIYDPLR YSVKTSRRVC ICLATFPYVY GFSDGLFQAI LTFRLTFCRS SVINHFYCAD
181 PPLIKLSCSD TYVKEHAMFI SAGFNLSSSL TIVLVSYAFI LAAILRIKSA EGRHKAFSTC
241 GSHMMAVTLF YGTLFCMYIR PPTDKTVEES KIIAVFYTFV SPVLNPLIYS LRNKDVKQAL
301 KNVLRLocalizationUniProt · AlphaFold · HPA
Whether an antibody against OR5M11 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Cell surface
- Secreted
- No
- Transmembrane segments
- 7
- Mean surface accessibility (rSASA)
- 0.27
- Highest tissue expression
- 0.1 nTPM
Expression across tissuesHPA
Tissue
- testis: 0.1 nTPM
- urinary bladder: 0.1 nTPM
- adipose tissue: 0 nTPM
- adrenal gland: 0 nTPM
- amygdala: 0 nTPM
- appendix: 0 nTPM
Single-cell type
- late spermatids: 4.2 nCPM
- early spermatids: 0.3 nCPM
- goblet cells: 0.2 nCPM
- late primary spermatocytes: 0.1 nCPM
- respiratory secretory cells: 0.1 nCPM
- urothelial cells: 0.1 nCPM
Immune cell
- basophil: 0 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
- gdT-cell: 0 nTPM
- intermediate monocyte: 0 nTPM
- MAIT T-cell: 0 nTPM
Brain region
- amygdala: 0 nTPM
- basal ganglia: 0 nTPM
- cerebellum: 0 nTPM
- cerebral cortex: 0 nTPM
- choroid plexus: 0 nTPM
- hippocampal formation: 0 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.83
- gnomAD pLI
- 0
- gnomAD missense Z
- -0.51
- DepMap mean gene effect
- -0.14
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads OR5M11 as an antibody target. Whether an autoantibody or antibody against OR5M11 could matter depends on whether native OR5M11 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
OR5M11 is annotated at the cell surface, where native OR5M11 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.
Annotation status
The present source text does not explicitly label OR5M11 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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