Seroatlas · Human Serome Atlas

OR5K2

Olfactory receptor 5K2

Also known as: OR5K2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8NHB8
Gene: OR5K2
Ensembl: ENSG00000231861
Chromosome: 3
Canonical length: 316 aa
Protein class: G-protein coupled receptors, Predicted membrane proteins

OverviewNCBI Gene

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

316 residues, UniProt reviewed canonical sequence.

>Q8NHB8|OR5K2
     1  MVEENHTMKN EFILTGFTDH PELKTLLFVV FFAIYLITVV GNISLVALIF THCRLHTPMY
    61  IFLGNLALVD SCCACAITPK MLENFFSEGK RISLYECAVQ FYFLCTVETA DCFLLAAVAY
   121  DRYVAICNPL QYHIMMSKKL CIQMTTGAFI AGNLHSMIHV GLVFRLVFCG LNHINHFYCD
   181  TLPLYRLSCV DPFINELVLF IFSGSVQVFT IGSVLISYLY ILLTIFRMKS KEGRAKAFST
   241  CASHFSSVSL FYGSIFFLYI RPNLLEEGGN DIPAAILFTI VVPLLNPFIY SLRNKEVISV
   301  LRKILLKIKS QGSVNK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against OR5K2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 7
Mean surface accessibility (rSASA): 0.27
Highest tissue expression: 0.8 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 0.8 nTPM
cerebellum: 0.6 nTPM
blood vessel: 0.5 nTPM
colon: 0.5 nTPM
small intestine: 0.5 nTPM
basal ganglia: 0.4 nTPM

Single-cell type

cardiomyocytes: 1.8 nCPM
fibroblasts: 0.1 nCPM
vascular endothelial cells: 0.1 nCPM
adipocytes: 0 nCPM
adrenal cortex cells: 0 nCPM
adrenal medulla cells: 0 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

basal ganglia: 0.8 nTPM
cerebellum: 0.8 nTPM
cerebral cortex: 0.5 nTPM
white matter: 0.5 nTPM
amygdala: 0.3 nTPM
hippocampal formation: 0.3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.85
gnomAD pLI: 0
gnomAD missense Z: -1.04

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

Cellular components

plasma membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads OR5K2 as an antibody target. Whether an autoantibody or antibody against OR5K2 could matter depends on whether native OR5K2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

OR5K2 is annotated at the cell surface, where native OR5K2 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label OR5K2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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