Seroatlas · Human Serome Atlas

OR5H14

Olfactory receptor 5H14

Also known as: O5H14_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: A6NHG9
Gene: OR5H14
Ensembl: ENSG00000236032
Chromosome: 3
Canonical length: 310 aa
Protein class: G-protein coupled receptors, Predicted membrane proteins

OverviewNCBI Gene

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

310 residues, UniProt reviewed canonical sequence.

>A6NHG9|OR5H14
     1  MEEENATLLT EFVLTGFLYQ PQWKIPLFLA FLVIYLITIM GNLGLIAVIW KDPHLHIPMY
    61  LLLGNLAFVD ALLSSSVTLK MLINFLAKSK MISLSECKIQ LFSFAISVTT ECFLLATMAY
   121  DRYVAICKPL LYPAIMTNGL CIRLLILSYV GGLLHALIHE GFLFRLTFCN SNIIQHFYCD
   181  IIPLLKISYT DSSINFLMVF IFAGSIQVFT IGTVLISYIF VLYTILKKKS VKGMRKAFST
   241  CGAHLLSVSL YYGPLAFMYM GSASPQADDQ DMMESLFYTV IVPLLNPMIY SLRNKQVIAS
   301  FTKMFKRNDV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against OR5H14 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 7
Mean surface accessibility (rSASA): 0.27
Highest tissue expression: 0.3 nTPM

Expression across tissuesHPA

Tissue

placenta: 0.3 nTPM
bone marrow: 0.2 nTPM
choroid plexus: 0.1 nTPM
retina: 0.1 nTPM
skin: 0.1 nTPM
testis: 0.1 nTPM

Single-cell type

late primary spermatocytes: 2 nCPM
early spermatids: 1.9 nCPM
late spermatids: 0.7 nCPM
extravillous trophoblasts: 0.3 nCPM
monocyte progenitors: 0.3 nCPM
podocytes: 0.3 nCPM

Immune cell

basophil: 0.3 nTPM
neutrophil: 0.1 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM

Brain region

cerebellum: 3.3 nTPM
white matter: 2.9 nTPM
cerebral cortex: 2.8 nTPM
hypothalamus: 2.5 nTPM
pons: 2.5 nTPM
amygdala: 2.3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.94
gnomAD pLI: 0
gnomAD missense Z: -1.9
DepMap mean gene effect: 0.06
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 1% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

Cellular components

plasma membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads OR5H14 as an antibody target. Whether an autoantibody or antibody against OR5H14 could matter depends on whether native OR5H14 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

OR5H14 is annotated at the cell surface, where native OR5H14 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label OR5H14 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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