Seroatlas · Human Serome Atlas

OR5H1

Olfactory receptor 5H1

Also known as: HSHTPCRX14, HTPCRX14, OR5H1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: A6NKK0
Gene: OR5H1
Ensembl: ENSG00000231192
Chromosome: 3
Canonical length: 313 aa
Protein class: G-protein coupled receptors, Predicted membrane proteins

OverviewNCBI Gene

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

313 residues, UniProt reviewed canonical sequence.

>A6NKK0|OR5H1
     1  MEEENATLLT EFVLTGFLYQ PQWKIPLFLA FLVIYLITIM GNLGLIAVIW KDPHLHIPMY
    61  LLLGNLAFVD AWISSTVTPK MLNNFLAKSK MISLSECKIQ FFSFAISVTT ECFLLATMAY
   121  DRYVAICKPL LYPAIMTNGL CIRLLILSYV GGILHALIHE GFLFRLTFCN SNIVHHIYCD
   181  TIPLSKISCT DSSINFLMVF IFSGSIQVFS IVTILVSYTF VLFAILKKKS DKGVRKAFST
   241  CGAHLFSVSL YYGPLLFIYV GPASPQADDQ DMVEPLFYTV IIPLLNPIIY SLRNKQVTVS
   301  FTKMLKKHVK VSY

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against OR5H1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 7
Mean surface accessibility (rSASA): 0.28
Highest tissue expression: 0.2 nTPM

Expression across tissuesHPA

Tissue

retina: 0.2 nTPM
lymph node: 0.1 nTPM
spleen: 0.1 nTPM
testis: 0.1 nTPM
adipose tissue: 0 nTPM
adrenal gland: 0 nTPM

Single-cell type

extravillous trophoblasts: 0.2 nCPM
neutrophils: 0.2 nCPM
cardiomyocytes: 0.1 nCPM
late primary spermatocytes: 0.1 nCPM
migrating cytotrophoblasts: 0.1 nCPM
syncytiotrophoblasts: 0.1 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebral cortex: 2 nTPM
amygdala: 1.6 nTPM
medulla oblongata: 1.6 nTPM
pons: 1.6 nTPM
white matter: 1.6 nTPM
cerebellum: 1.5 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.87
gnomAD pLI: 0
gnomAD missense Z: -2.24

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 1% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

Cellular components

plasma membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads OR5H1 as an antibody target. Whether an autoantibody or antibody against OR5H1 could matter depends on whether native OR5H1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

OR5H1 is annotated at the cell surface, where native OR5H1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label OR5H1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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