Seroatlas · Human Serome Atlas

OR5G3

Olfactory receptor 5G3

Also known as: OR5G3_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P0C626
Gene: OR5G3
Canonical length: 314 aa
Protein class: Predicted membrane proteins

OverviewNCBI Gene

No narrative summary is available for OR5G3 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

314 residues, UniProt reviewed canonical sequence.

>P0C626|OR5G3
     1  MEDKNQTVVT EFLLLGLTDH PYQKIVLFFM FLFVYLITLG GNLGMITLIW IDPRLHTPMY
    61  FFLRHLSFVD ICSSSSVVPK MLCNIFAEKK DITFLGCAAQ MWFFGLFEAA ECFLLAAMAY
   121  DRYVAICKPL LYTLIMSQQV CMQLVVGPYA MALISTMTHT IFTFCLPFCG SNIINHFFCD
   181  IFPLLSLACA DTWVNKFVLF VLAGAIGVLS GLIIMVSYIC ILMTILKIQT ADGKQKAFFT
   241  CFSHLAAVSI LYGTLFLIYV RPSSSSSLGI YKVISLFYTV VIPMVNPLIY SLRNKEVKDA
   301  FRRKIERKKF IIGR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against OR5G3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 7
Mean surface accessibility (rSASA): 0.28
Highest tissue expression: 2.3 nTPM

Expression across tissuesHPA

Tissue

salivary gland: 2.3 nTPM
spleen: 1.4 nTPM
rectum: 0.2 nTPM
adipose tissue: 0 nTPM
adrenal gland: 0 nTPM
appendix: 0 nTPM

Single-cell type

adipocytes: 0 nCPM
adrenal cortex cells: 0 nCPM
adrenal medulla cells: 0 nCPM
alveolar cells type 1: 0 nCPM
alveolar cells type 2: 0 nCPM
astrocytes: 0 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

white matter: 0.5 nTPM
hypothalamus: 0.2 nTPM
medulla oblongata: 0.2 nTPM
pons: 0.2 nTPM
spinal cord: 0.2 nTPM
cerebral cortex: 0.1 nTPM

OntologyGO

Molecular functions

Cellular components

plasma membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads OR5G3 as an antibody target. Whether an autoantibody or antibody against OR5G3 could matter depends on whether native OR5G3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

OR5G3 is annotated at the cell surface, where native OR5G3 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label OR5G3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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