Seroatlas · Human Serome Atlas

OR5B21

Olfactory receptor 5B21

Also known as: O5B21_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: A6NL26
Gene: OR5B21
Ensembl: ENSG00000198283
Chromosome: 11
Canonical length: 309 aa
Protein class: G-protein coupled receptors, Predicted membrane proteins

OverviewNCBI Gene

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

309 residues, UniProt reviewed canonical sequence.

>A6NL26|OR5B21
     1  MENSTEVTEF ILLGLTDDPN LQIPLLLAFL FIYLITLLGN GGMMVIIHSD SHLHTPMYFF
    61  LSNLSLVDLG YSSAVAPKTV AALRSGDKAI SYDGCAAQFF FFVGFATVEC YLLASMAYDR
   121  HAAVCRPLHY TTTMTAGVCA LLATGSYVSG FLNASIHAAG TFRLSFCGSN EINHFFCDIP
   181  PLLALSCSDT RISKLVVFVA GFNVFFTLLV ILISYFFICI TIQRMHSAEG QKKVFSTCAS
   241  HLTALSIFYG TIIFMYLQPN SSQSVDTDKI ASVFYTVVIP MLNPLIYSLR NKEVKSALWK
   301  ILNKLYPQY

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against OR5B21 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 7
Mean surface accessibility (rSASA): 0.28
Highest tissue expression: 0.2 nTPM

Expression across tissuesHPA

Tissue

testis: 0.2 nTPM
adipose tissue: 0 nTPM
adrenal gland: 0 nTPM
amygdala: 0 nTPM
appendix: 0 nTPM
basal ganglia: 0 nTPM

Single-cell type

pdcs: 1.9 nCPM
monocytes: 0.7 nCPM
innate lymphoid cells: 0.5 nCPM
macrophages: 0.2 nCPM
nk-cells: 0.2 nCPM
cdc: 0.1 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebral cortex: 0.4 nTPM
cerebellum: 0.3 nTPM
white matter: 0.3 nTPM
amygdala: 0.2 nTPM
basal ganglia: 0.2 nTPM
hippocampal formation: 0.2 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.94
gnomAD pLI: 0
gnomAD missense Z: -0.05
DepMap mean gene effect: -0.09
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

plasma membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads OR5B21 as an antibody target. Whether an autoantibody or antibody against OR5B21 could matter depends on whether native OR5B21 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

OR5B21 is annotated at the cell surface, where native OR5B21 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label OR5B21 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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