Seroatlas · Human Serome Atlas

OR5B2

Olfactory receptor 5B2

Also known as: OR5B2_HUMAN, OST073

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96R09
Gene: OR5B2
Ensembl: ENSG00000172365
Chromosome: 11
Canonical length: 309 aa
Protein class: G-protein coupled receptors, Predicted membrane proteins

OverviewNCBI Gene

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

309 residues, UniProt reviewed canonical sequence.

>Q96R09|OR5B2
     1  MENCTEVTKF ILLGLTSVPE LQIPLFILFT FIYLLTLCGN LGMMLLILMD SCLHTPMYFF
    61  LSNLSLVDFG YSSAVTPKVM AGFLRGDKVI SYNACAVQMF FFVALATVEN YLLASMAYDR
   121  YAAVCKPLHY TTTMTASVGA CLALGSYVCG FLNASFHIGG IFSLSFCKSN LVHHFFCDVP
   181  AVMALSCSDK HTSEVILVFM SSFNIFFVLL VIFISYLFIF ITILKMHSAK GHQKALSTCA
   241  SHFTAVSVFY GTVIFIYLQP SSSHSMDTDK MASVFYAMII PMLNPVVYSL RNREVQNAFK
   301  KVLRRQKFL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against OR5B2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 7
Mean surface accessibility (rSASA): 0.27
Highest tissue expression: 0.2 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 0.2 nTPM
retina: 0.2 nTPM
testis: 0.1 nTPM
adipose tissue: 0 nTPM
adrenal gland: 0 nTPM
amygdala: 0 nTPM

Single-cell type

late primary spermatocytes: 0.2 nCPM
mast cells: 0.2 nCPM
peritubular myoid cells: 0.2 nCPM
pituitary stem cells: 0.2 nCPM
undifferentiated spermatogonia: 0.2 nCPM
astrocytes: 0.1 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebellum: 3.1 nTPM
white matter: 1.9 nTPM
cerebral cortex: 1.6 nTPM
choroid plexus: 1.6 nTPM
basal ganglia: 1.5 nTPM
hypothalamus: 1.5 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.47
gnomAD pLI: 0.07
gnomAD missense Z: -0.63
DepMap mean gene effect: -0.09
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

plasma membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads OR5B2 as an antibody target. Whether an autoantibody or antibody against OR5B2 could matter depends on whether native OR5B2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

OR5B2 is annotated at the cell surface, where native OR5B2 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label OR5B2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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