Seroatlas · Human Serome Atlas

OR5AU1

Olfactory receptor 5AU1

Also known as: O5AU1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8NGC0
Gene: OR5AU1
Ensembl: ENSG00000169327
Chromosome: 14
Canonical length: 362 aa
Protein class: G-protein coupled receptors, Predicted membrane proteins

OverviewNCBI Gene

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

362 residues, UniProt reviewed canonical sequence.

>Q8NGC0|OR5AU1
     1  MTEFHLQSQM PSIRLIFRRL SLGRIKPSQS PRCSTSFMVV PSFSIAEHWR RMKGANLSQG
    61  MEFELLGLTT DPQLQRLLFV VFLGMYTATL LGNLVMFLLI HVSATLHTPM YSLLKSLSFL
   121  DFCYSSTVVP QTLVNFLAKR KVISYFGCMT QMFFYAGFAT SECYLIAAMA YDRYAAICNP
   181  LLYSTIMSPE VCASLIVGSY SAGFLNSLIH TGCIFSLKFC GAHVVTHFFC DGPPILSLSC
   241  VDTSLCEILL FIFAGFNLLS CTLTILISYF LILNTILKMS SAQGRFKAFS TCASHLTAIC
   301  LFFGTTLFMY LRPRSSYSLT QDRTVAVIYT VVIPVLNPLM YSLRNKDVKK ALIKVWGRKT
   361  ME

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against OR5AU1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 7
Mean surface accessibility (rSASA): 0.34
Highest tissue expression: 0.4 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 0.4 nTPM
skeletal muscle: 0.2 nTPM
breast: 0.1 nTPM
duodenum: 0.1 nTPM
epididymis: 0.1 nTPM
heart muscle: 0.1 nTPM

Single-cell type

endometrial luminal cells: 5 nCPM
endometrial glandular cells: 3.5 nCPM
epididymal basal cells: 2 nCPM
epididymal clear cells: 2 nCPM
breast myoepithelial cells: 1.7 nCPM
mesothelial cells: 1.3 nCPM

Immune cell

neutrophil: 0.3 nTPM
basophil: 0.2 nTPM
classical monocyte: 0.1 nTPM
naive B-cell: 0.1 nTPM
NK-cell: 0.1 nTPM
plasmacytoid DC: 0.1 nTPM

Brain region

cerebellum: 3.2 nTPM
cerebral cortex: 3 nTPM
white matter: 2.7 nTPM
basal ganglia: 2.6 nTPM
hippocampal formation: 2.6 nTPM
amygdala: 2.5 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.89
gnomAD pLI: 0
gnomAD missense Z: -1.25
DepMap mean gene effect: -0.21
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

Cellular components

plasma membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads OR5AU1 as an antibody target. Whether an autoantibody or antibody against OR5AU1 could matter depends on whether native OR5AU1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

OR5AU1 is annotated at the cell surface, where native OR5AU1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label OR5AU1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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